Detailed information of TA system TA096607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2496860..2497515
• Replicon: chromosome
• Accession: NZ_CP026916
• Organism: Bordetella pertussis strain J546

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: C5E85_RS12135
• Protein ID: WP_047122780.1
• Coordinates: 2497264..2497515 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: C5E85_RS12130
• Protein ID: WP_003809516.1
• Coordinates: 2496860..2497261 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5E85_RS12100	2492043..2493065	-	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-
C5E85_RS12105	2493202..2494239	-	1038	WP_023853543.1	threonylcarbamoyl-AMP synthase	-
C5E85_RS12110	2494259..2495449	-	1191	WP_010930406.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
C5E85_RS12115	2495452..2495967	-	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
C5E85_RS12120	2496117..2496596	-	480	WP_010930405.1	disulfide bond formation protein B	-
C5E85_RS12125	2496604..2496840	-	237	WP_010930404.1	membrane protein	-
C5E85_RS12130	2496860..2497261	-	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
C5E85_RS12135	2497264..2497515	-	252	WP_047122780.1	type II toxin-antitoxin system MqsR family toxin	Toxin
C5E85_RS12140	2497570..2498451	-	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
C5E85_RS12145	2498676..2499122	+	447	WP_003819827.1	GFA family protein	-
C5E85_RS12150	2499207..2500271	-	1065	WP_003809510.1	fructose-bisphosphate aldolase class II	-
C5E85_RS12155	2500408..2500989	-	582	WP_019247931.1	molybdenum cofactor biosysynthesis protein	-
C5E85_RS12160	2501224..2502354	+	1131	WP_010930401.1	helix-turn-helix transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8952.52 Da
• Isoelectric Point: 9.7242

>T96607 WP_047122780.1 NZ_CP026916:c2497515-2497264 [Bordetella pertussis]
IGGAATKKPGQKRRAGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T96607 NZ_CP026916:c2497515-2497264 [Bordetella pertussis]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAATCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT96607 WP_003809516.1 NZ_CP026916:c2497261-2496860 [Bordetella pertussis]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT96607 NZ_CP026916:c2497261-2496860 [Bordetella pertussis]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCTGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6