Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 204040..204695 Replicon chromosome
Accession NZ_CP026881
Organism Pseudomonas sp. LG1D9

Toxin (Protein)


Gene name higB Uniprot ID A0A1S1UXS8
Locus tag C5F71_RS00965 Protein ID WP_070995472.1
Coordinates 204040..204384 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1S1UVI2
Locus tag C5F71_RS00970 Protein ID WP_070995473.1
Coordinates 204381..204695 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5F71_RS00955 200798..202330 + 1533 WP_029293337.1 NADH-quinone oxidoreductase subunit M -
C5F71_RS00960 202338..203801 + 1464 WP_029293335.1 NADH-quinone oxidoreductase subunit NuoN -
C5F71_RS00965 204040..204384 + 345 WP_070995472.1 toxin Toxin
C5F71_RS00970 204381..204695 + 315 WP_070995473.1 transcriptional regulator Antitoxin
C5F71_RS00975 204769..206511 - 1743 WP_104910389.1 ABC transporter substrate-binding protein -
C5F71_RS00980 206678..206950 - 273 WP_029293327.1 DUF2160 domain-containing protein -
C5F71_RS00985 206961..207761 - 801 WP_017735079.1 carbohydrate ABC transporter permease -
C5F71_RS00990 207772..208638 - 867 WP_029293322.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-100)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13470.41 Da        Isoelectric Point: 9.9080

>T96533 WP_070995472.1 NZ_CP026881:204040-204384 [Pseudomonas sp. LG1D9]
MDALFIELPPFERYRKDYLTDELFHGFQQELMKNPEAGAVMEGTGGLRKLRFVDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEQSDLSPQHKKALKQLLDREINARGFT

Download         Length: 345 bp

>T96533 NZ_CP026881:204040-204384 [Pseudomonas sp. LG1D9]
ATGGATGCTCTATTTATCGAACTGCCGCCCTTTGAGCGGTACCGCAAGGACTACCTGACTGACGAACTGTTTCACGGCTT
TCAACAAGAGCTAATGAAGAACCCCGAAGCGGGAGCCGTGATGGAAGGCACCGGAGGGTTACGCAAGCTGCGCTTCGTCG
ATGAACGACGAAACAAAGGCAAACGGGGTGGATTACGCGTCATCTACTACTGGTGGTCAGGCGGCACTCAATTTTGGTTG
TTCACGCTGTACGGCAAGCACGAGCAAAGCGACTTGAGCCCACAACACAAAAAAGCCCTCAAGCAACTGCTGGACAGGGA
AATCAACGCGAGAGGATTCACATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11838.58 Da        Isoelectric Point: 10.5386

>AT96533 WP_070995473.1 NZ_CP026881:204381-204695 [Pseudomonas sp. LG1D9]
MKRDIYSELVEGFDALANERQGKVTLRTHTVQQNKLAPLTAEDVIAVRQQLNLSRAVFAMYLRTNTRTLENWEQGRARPN
AQAATLIRLVSKFPDTVERLALLS

Download         Length: 315 bp

>AT96533 NZ_CP026881:204381-204695 [Pseudomonas sp. LG1D9]
ATGAAACGTGACATTTATTCCGAACTGGTCGAAGGCTTCGATGCCTTGGCCAACGAGCGCCAAGGCAAGGTCACCCTACG
TACTCATACCGTGCAGCAAAACAAACTGGCCCCTCTTACCGCTGAAGACGTGATTGCAGTGCGACAACAACTCAATCTTT
CCCGTGCTGTATTTGCCATGTACCTACGCACCAATACACGCACCCTGGAAAACTGGGAGCAAGGTCGCGCACGCCCCAAT
GCCCAGGCAGCCACGTTGATTCGTCTGGTATCAAAATTCCCGGATACGGTGGAGCGCCTGGCGTTGCTTAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S1UXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1UVI2

References