Detailed information of TA system TA096412

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4002192..4002417
• Replicon: chromosome
• Accession: NZ_CP026840
• Organism: Shigella dysenteriae strain ATCC 9753

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P67_RS20850
• Protein ID: WP_000813254.1
• Coordinates: 4002262..4002417 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	4002192..4002250 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P67_RS20795	3997523..3997819	+	297	WP_001266130.1	DUF4406 domain-containing protein	-
C1P67_RS20800	3997816..3998277	+	462	WP_001209470.1	sigma-E factor regulatory protein RseB domain-containing protein	-
C1P67_RS20805	3998255..3998611	+	357	WP_000403782.1	hypothetical protein	-
C1P67_RS20810	3998707..3998889	+	183	WP_001224665.1	hypothetical protein	-
C1P67_RS26775	3998882..3999058	+	177	WP_000753053.1	hypothetical protein	-
C1P67_RS20815	3999055..3999414	+	360	WP_001289986.1	hypothetical protein	-
C1P67_RS20820	3999415..3999630	+	216	WP_000510387.1	hypothetical protein	-
C1P67_RS20825	3999632..3999850	+	219	WP_001142588.1	DUF4014 family protein	-
C1P67_RS20830	3999852..4000115	+	264	WP_000224215.1	hypothetical protein	-
C1P67_RS20835	4000126..4000293	+	168	WP_000207997.1	hypothetical protein	-
C1P67_RS20840	4000494..4001722	+	1229	WP_088895425.1	IS3-like element IS2 family transposase	-
C1P67_RS20845	4001737..4001970	+	234	WP_000350274.1	hypothetical protein	-
-	4002192..4002250	-	59	-	-	Antitoxin
C1P67_RS20850	4002262..4002417	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
C1P67_RS20855	4002634..4002885	+	252	WP_000980988.1	protein Rem	-
C1P67_RS27350	4002952..4003230	+	279	WP_032336987.1	hypothetical protein	-
C1P67_RS20865	4003232..4004278	+	1047	WP_001265101.1	DUF968 domain-containing protein	-
C1P67_RS20870	4004291..4004665	+	375	WP_000904114.1	RusA family crossover junction endodeoxyribonuclease	-
C1P67_RS20875	4004662..4005483	+	822	WP_000762933.1	antitermination protein	-
C1P67_RS20880	4005710..4005950	+	241	Protein_4020	hypothetical protein	-
C1P67_RS20885	4006058..4007116	+	1059	WP_000935541.1	site-specific DNA-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3983842..4040679	56837

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96412 WP_000813254.1 NZ_CP026840:4002262-4002417 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96412 NZ_CP026840:4002262-4002417 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGCTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96412 NZ_CP026840:c4002250-4002192 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin