Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2750924..2751182 Replicon chromosome
Accession NZ_CP026840
Organism Shigella dysenteriae strain ATCC 9753

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag C1P67_RS14280 Protein ID WP_000809168.1
Coordinates 2750924..2751076 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2751125..2751182 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P67_RS14255 2746127..2746303 - 177 Protein_2741 DUF2541 family protein -
C1P67_RS14265 2747078..2747308 - 231 Protein_2743 DUF2541 family protein -
C1P67_RS14270 2747685..2749601 + 1917 WP_000516135.1 molecular chaperone DnaK -
C1P67_RS14275 2749690..2750820 + 1131 WP_001118467.1 molecular chaperone DnaJ -
C1P67_RS14280 2750924..2751076 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 2751125..2751182 + 58 - - Antitoxin
C1P67_RS14285 2751662..2752828 + 1167 WP_000681369.1 Na+/H+ antiporter NhaA -
C1P67_RS14290 2752894..2753793 + 900 WP_001300855.1 transcriptional activator NhaR -
C1P67_RS14295 2753830..2754264 - 435 Protein_2749 fimbrial family protein -
C1P67_RS14300 2754355..2755583 + 1229 WP_134805288.1 IS3-like element IS2 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2746326..2746829 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T96409 WP_000809168.1 NZ_CP026840:c2751076-2750924 [Shigella dysenteriae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T96409 NZ_CP026840:c2751076-2750924 [Shigella dysenteriae]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT96409 NZ_CP026840:2751125-2751182 [Shigella dysenteriae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References