Detailed information of TA system TA096402

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 102354..102579
• Replicon: chromosome
• Accession: NZ_CP026840
• Organism: Shigella dysenteriae strain ATCC 9753

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P67_RS00620
• Protein ID: WP_000813254.1
• Coordinates: 102354..102509 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	102521..102579 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P67_RS00575	97428..98125	+	698	WP_284520991.1	IS1-like element IS1SD family transposase	-
C1P67_RS26590	98142..98444	-	303	Protein_108	phage tail protein	-
C1P67_RS00585	99121..99711	-	591	Protein_109	DUF2313 domain-containing protein	-
C1P67_RS00590	99711..99935	-	225	WP_073691608.1	hypothetical protein	-
C1P67_RS00595	99951..101107	+	1157	WP_094096479.1	IS3-like element IS600 family transposase	-
C1P67_RS00605	101157..101906	-	750	Protein_112	hypothetical protein	-
C1P67_RS00610	101908..102186	-	279	WP_000929754.1	hypothetical protein	-
C1P67_RS00620	102354..102509	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	102521..102579	+	59	-	-	Antitoxin
C1P67_RS00635	103161..103577	-	417	WP_005069274.1	hypothetical protein	-
C1P67_RS00640	103689..104069	+	381	WP_001333468.1	transposase	-
C1P67_RS00645	104066..104413	+	348	WP_000612626.1	IS66 family insertion sequence element accessory protein TnpB	-
C1P67_RS00650	104462..106000	+	1539	WP_000099181.1	IS66-like element ISEc22 family transposase	-
C1P67_RS00655	106050..106505	-	456	WP_000335375.1	ead/Ea22-like family protein	-
C1P67_RS00660	106492..106797	-	306	WP_001266147.1	DUF4406 domain-containing protein	-
C1P67_RS00665	106794..107216	-	423	WP_001151146.1	DUF977 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ipaH9.8	71996..147930	75934
	-	inside	IScluster/Tn	-	-	97748..110262	12514

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96402 WP_000813254.1 NZ_CP026840:c102509-102354 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96402 NZ_CP026840:c102509-102354 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96402 NZ_CP026840:102521-102579 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin