96399

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3836920..3837647 Replicon chromosome
Accession NZ_CP026839
Organism Shigella dysenteriae strain ATCC 9752

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag C1P69_RS20415 Protein ID WP_000550189.1
Coordinates 3836920..3837234 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C1P69_RS20420 Protein ID WP_000560263.1
Coordinates 3837231..3837647 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P69_RS20395 (3833086) 3833086..3834072 - 987 WP_001446103.1 Gfo/Idh/MocA family oxidoreductase -
C1P69_RS20400 (3834151) 3834151..3834834 - 684 WP_134804089.1 vancomycin high temperature exclusion protein -
C1P69_RS20405 (3834911) 3834911..3835414 - 504 WP_001295542.1 M48 family metallopeptidase -
C1P69_RS20410 (3835499) 3835499..3836635 + 1137 WP_134804090.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
C1P69_RS20415 (3836920) 3836920..3837234 + 315 WP_000550189.1 type II toxin-antitoxin system toxin HigB Toxin
C1P69_RS20420 (3837231) 3837231..3837647 + 417 WP_000560263.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
C1P69_RS20425 (3837692) 3837692..3839710 - 2019 WP_134804091.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
C1P69_RS23770 (3839936) 3839936..3842285 - 2350 Protein_3805 alpha-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T96399 WP_000550189.1 NZ_CP026839:3836920-3837234 [Shigella dysenteriae]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T96399 NZ_CP026839:3836920-3837234 [Shigella dysenteriae]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14979.42 Da        Isoelectric Point: 4.4547

>AT96399 WP_000560263.1 NZ_CP026839:3837231-3837647 [Shigella dysenteriae]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLADLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT96399 NZ_CP026839:3837231-3837647 [Shigella dysenteriae]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCGGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTGCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6KMQ
PDB 5IFG
PDB 5YCL
PDB 6KML

Antitoxin

Source ID Structure

References