Detailed information of TA system TA096395

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2661214..2661439
• Replicon: chromosome
• Accession: NZ_CP026839
• Organism: Shigella dysenteriae strain ATCC 9752

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P69_RS14450
• Protein ID: WP_000813254.1
• Coordinates: 2661214..2661369 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2661381..2661439 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P69_RS14415	2656265..2657323	-	1059	WP_134803738.1	site-specific DNA-methyltransferase	-
C1P69_RS14420	2657431..2657671	-	241	Protein_2657	hypothetical protein	-
C1P69_RS14425	2657883..2658571	-	689	Protein_2658	bacteriophage antitermination protein Q	-
C1P69_RS14430	2658568..2658909	-	342	WP_134804226.1	RusA family crossover junction endodeoxyribonuclease	-
C1P69_RS14435	2658964..2659661	+	698	WP_284526035.1	IS1 family transposase	-
C1P69_RS14440	2659711..2660766	-	1056	WP_134803739.1	DUF968 domain-containing protein	-
C1P69_RS22855	2660768..2661046	-	279	WP_158252698.1	hypothetical protein	-
C1P69_RS14450	2661214..2661369	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2661381..2661439	+	59	-	-	Antitoxin
C1P69_RS14455	2661593..2662584	+	992	Protein_2664	IS3 family transposase	-
C1P69_RS14465	2663831..2664058	+	228	Protein_2666	integrase core domain-containing protein	-
C1P69_RS14475	2664169..2664834	-	666	WP_000150294.1	epoxyqueuosine reductase QueH	-
C1P69_RS14480	2665009..2665434	-	426	Protein_2668	DUF977 family protein	-
C1P69_RS14485	2665450..2666220	-	771	WP_000451003.1	DUF1627 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2620825..2679340	58515
	-	inside	IScluster/Tn	-	-	2659158..2672292	13134

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96395 WP_000813254.1 NZ_CP026839:c2661369-2661214 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96395 NZ_CP026839:c2661369-2661214 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96395 NZ_CP026839:2661381-2661439 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin