Detailed information of TA system TA096393

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1912738..1912963
• Replicon: chromosome
• Accession: NZ_CP026839
• Organism: Shigella dysenteriae strain ATCC 9752

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P69_RS10255
• Protein ID: WP_000813254.1
• Coordinates: 1912808..1912963 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1912738..1912796 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P69_RS10205	1907836..1908261	+	426	WP_000693847.1	toxin YdaT family protein	-
C1P69_RS10210	1908333..1908674	+	342	WP_171765608.1	hypothetical protein	-
C1P69_RS10215	1908771..1909392	+	622	Protein_1843	phage replisome organizer	-
C1P69_RS10220	1909426..1909848	+	423	WP_001151146.1	DUF977 family protein	-
C1P69_RS10225	1909845..1910150	+	306	WP_134803558.1	DUF4406 domain-containing protein	-
C1P69_RS23500	1910188..1910631	+	444	WP_284526212.1	ead/Ea22-like family protein	-
C1P69_RS10235	1910513..1911725	-	1213	Protein_1847	IS3 family transposase	-
C1P69_RS10240	1911784..1912041	+	258	Protein_1848	integrase core domain-containing protein	-
-	1912738..1912796	-	59	-	-	Antitoxin
C1P69_RS10255	1912808..1912963	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
C1P69_RS10260	1913131..1913407	+	277	Protein_1850	hypothetical protein	-
C1P69_RS10265	1913409..1914158	+	750	Protein_1851	hypothetical protein	-
C1P69_RS10275	1914208..1914987	-	780	Protein_1852	IS3-like element IS600 family transposase	-
C1P69_RS10285	1916300..1916676	-	377	Protein_1854	transposase	-
C1P69_RS10290	1916742..1916876	+	135	Protein_1855	DUF1133 family protein	-
C1P69_RS10315	1917669..1917851	+	183	WP_134803559.1	phage holin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ipaH7.8	1891603..1939821	48218
	-	inside	IScluster/Tn	-	ipaH7.8	1902390..1925287	22897

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96393 WP_000813254.1 NZ_CP026839:1912808-1912963 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96393 NZ_CP026839:1912808-1912963 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96393 NZ_CP026839:c1912796-1912738 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin