Detailed information of TA system TA096391

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1126876..1127134
• Replicon: chromosome
• Accession: NZ_CP026839
• Organism: Shigella dysenteriae strain ATCC 9752

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: C1P69_RS06375
• Protein ID: WP_000809168.1
• Coordinates: 1126876..1127028 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1127077..1127134 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P69_RS06355	1122233..1122830	-	598	Protein_1089	ubiquinol-cytochrome C chaperone family protein	-
C1P69_RS06360	1122856..1123260	-	405	WP_044067255.1	DUF2541 family protein	-
C1P69_RS06365	1123637..1125553	+	1917	WP_023278178.1	molecular chaperone DnaK	-
C1P69_RS06370	1125642..1126772	+	1131	WP_001118467.1	molecular chaperone DnaJ	-
C1P69_RS06375	1126876..1127028	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	1127077..1127134	+	58	-	-	Antitoxin
C1P69_RS06380	1127614..1128780	+	1167	WP_134803351.1	Na+/H+ antiporter NhaA	-
C1P69_RS06385	1128846..1129745	+	900	WP_001300855.1	transcriptional activator NhaR	-
C1P69_RS06390	1129783..1130256	-	474	Protein_1096	fimbrial family protein	-
C1P69_RS06395	1130312..1131009	+	698	WP_094106546.1	IS1 family transposase	-
C1P69_RS06400	1131243..1131506	-	264	WP_001274021.1	30S ribosomal protein S20	-
C1P69_RS06405	1131609..1131827	+	219	WP_001295417.1	DUF2575 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1130506..1131009	503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T96391 WP_000809168.1 NZ_CP026839:c1127028-1126876 [Shigella dysenteriae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T96391 NZ_CP026839:c1127028-1126876 [Shigella dysenteriae]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT96391 NZ_CP026839:1127077-1127134 [Shigella dysenteriae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin