Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3534382..3534640 Replicon chromosome
Accession NZ_CP026834
Organism Shigella dysenteriae strain ATCC 49347

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag C5B83_RS18550 Protein ID WP_000809168.1
Coordinates 3534382..3534534 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3534583..3534640 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B83_RS18525 3529600..3529776 - 177 Protein_3579 DUF2541 family protein -
C5B83_RS18535 3530551..3530781 - 231 Protein_3581 DUF2541 family protein -
C5B83_RS18540 3531158..3533074 + 1917 WP_000516135.1 molecular chaperone DnaK -
C5B83_RS18545 3533163..3534278 + 1116 WP_001118451.1 molecular chaperone DnaJ -
C5B83_RS18550 3534382..3534534 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3534583..3534640 + 58 - - Antitoxin
C5B83_RS18555 3535120..3536286 + 1167 WP_000681373.1 Na+/H+ antiporter NhaA -
C5B83_RS18560 3536352..3537251 + 900 WP_001300855.1 transcriptional activator NhaR -
C5B83_RS18565 3537289..3537723 - 435 Protein_3587 fimbrial family protein -
C5B83_RS18570 3537814..3539042 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3529799..3530302 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T96354 WP_000809168.1 NZ_CP026834:c3534534-3534382 [Shigella dysenteriae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T96354 NZ_CP026834:c3534534-3534382 [Shigella dysenteriae]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT96354 NZ_CP026834:3534583-3534640 [Shigella dysenteriae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References