Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2559720..2559977 Replicon chromosome
Accession NZ_CP026834
Organism Shigella dysenteriae strain ATCC 49347

Toxin (Protein)


Gene name hokA Uniprot ID Q31V67
Locus tag C5B83_RS13680 Protein ID WP_001135724.1
Coordinates 2559825..2559977 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 2559720..2559774 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B83_RS13650 2555229..2555459 - 231 Protein_2649 IS4 family transposase -
C5B83_RS13655 2555463..2555672 - 210 Protein_2650 IS66 family insertion sequence element accessory protein TnpB -
C5B83_RS13660 2555669..2556025 - 357 WP_000239757.1 transposase -
C5B83_RS13665 2556176..2557318 + 1143 Protein_2652 IS4-like element IS4 family transposase -
- 2559720..2559774 - 55 - - Antitoxin
C5B83_RS13680 2559825..2559977 + 153 WP_001135724.1 type I toxin-antitoxin system toxin HokA Toxin
C5B83_RS26070 2559966..2560025 - 60 WP_212732943.1 hypothetical protein -
C5B83_RS13685 2560156..2560368 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
C5B83_RS13690 2560649..2560939 - 291 WP_005045913.1 HTH-type transcriptional regulator -
C5B83_RS13700 2562148..2562858 + 711 WP_004987320.1 DUF3053 domain-containing protein -
C5B83_RS13705 2562908..2563882 - 975 WP_000805034.1 glyoxylate/hydroxypyruvate reductase GhrB -
C5B83_RS13710 2563986..2564573 - 588 WP_000747616.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2555669..2561571 5902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5868.09 Da        Isoelectric Point: 7.7173

>T96351 WP_001135724.1 NZ_CP026834:2559825-2559977 [Shigella dysenteriae]
MPQKYGLLSLIVICFTLLFFTWMVRDSLCELHIKQGRYELAAFLACNLKE

Download         Length: 153 bp

>T96351 NZ_CP026834:2559825-2559977 [Shigella dysenteriae]
ATGCCGCAAAAATACGGATTACTTTCATTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGGTAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGCGTTATGAGCTAGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT96351 NZ_CP026834:c2559774-2559720 [Shigella dysenteriae]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q31V67

Antitoxin

Download structure file

References