Detailed information of TA system TA096344

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 895985..896210
• Replicon: chromosome
• Accession: NZ_CP026834
• Organism: Shigella dysenteriae strain ATCC 49347

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C5B83_RS05055
• Protein ID: WP_000813254.1
• Coordinates: 895985..896140 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	896152..896210 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5B83_RS05015	891133..892401	-	1269	Protein_977	prophage tail fiber N-terminal domain-containing protein	-
C5B83_RS05020	892425..892970	-	546	WP_000902849.1	tail fiber assembly protein	-
C5B83_RS25915	892973..893041	-	69	Protein_979	phage tail protein	-
C5B83_RS05025	893097..893794	+	698	WP_134795416.1	IS1-like element IS1SD family transposase	-
C5B83_RS05030	893810..894738	+	929	Protein_981	IS3-like element IS600 family transposase	-
C5B83_RS05040	894788..895537	-	750	Protein_982	hypothetical protein	-
C5B83_RS05045	895539..895817	-	279	WP_000929754.1	hypothetical protein	-
C5B83_RS05055	895985..896140	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	896152..896210	+	59	-	-	Antitoxin
C5B83_RS05070	896792..897208	-	417	WP_005069274.1	hypothetical protein	-
C5B83_RS05075	897320..897700	+	381	WP_001333468.1	transposase	-
C5B83_RS05080	897697..898044	+	348	WP_000612610.1	IS66 family insertion sequence element accessory protein TnpB	-
C5B83_RS05085	898093..899631	+	1539	WP_000099181.1	IS66-like element ISEc22 family transposase	-
C5B83_RS05090	899681..900136	-	456	WP_000335375.1	ead/Ea22-like family protein	-
C5B83_RS05095	900123..900428	-	306	WP_001266147.1	DUF4406 domain-containing protein	-
C5B83_RS05100	900425..900847	-	423	WP_001151146.1	DUF977 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ipaH9.8	866272..919379	53107
	-	inside	IScluster/Tn	-	-	893417..904658	11241

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96344 WP_000813254.1 NZ_CP026834:c896140-895985 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96344 NZ_CP026834:c896140-895985 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96344 NZ_CP026834:896152-896210 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin