Detailed information of TA system TA096334

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 101708..101933
• Replicon: chromosome
• Accession: NZ_CP026834
• Organism: Shigella dysenteriae strain ATCC 49347

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C5B83_RS00565
• Protein ID: WP_000813254.1
• Coordinates: 101778..101933 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	101708..101766 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5B83_RS00510	97040..97336	+	297	WP_001266130.1	DUF4406 domain-containing protein	-
C5B83_RS00515	97333..97794	+	462	WP_001209470.1	sigma-E factor regulatory protein RseB domain-containing protein	-
C5B83_RS00520	97772..98128	+	357	WP_000403782.1	hypothetical protein	-
C5B83_RS00525	98224..98406	+	183	WP_001224665.1	hypothetical protein	-
C5B83_RS25465	98399..98575	+	177	WP_000753053.1	hypothetical protein	-
C5B83_RS00530	98572..98931	+	360	WP_001289986.1	hypothetical protein	-
C5B83_RS00535	98932..99147	+	216	WP_000510387.1	hypothetical protein	-
C5B83_RS00540	99149..99367	+	219	WP_001142588.1	DUF4014 family protein	-
C5B83_RS00545	99369..99632	+	264	WP_000224216.1	hypothetical protein	-
C5B83_RS00550	99643..99810	+	168	WP_000207997.1	hypothetical protein	-
C5B83_RS00555	100010..101238	+	1229	WP_167544911.1	IS3-like element IS2 family transposase	-
C5B83_RS00560	101223..101486	+	264	WP_242412557.1	hypothetical protein	-
-	101708..101766	-	59	-	-	Antitoxin
C5B83_RS00565	101778..101933	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
C5B83_RS00570	102150..102401	+	252	WP_000980988.1	protein Rem	-
C5B83_RS00575	102468..102746	+	279	WP_032335658.1	hypothetical protein	-
C5B83_RS00580	102748..103794	+	1047	WP_001265091.1	DUF968 domain-containing protein	-
C5B83_RS00585	103807..104181	+	375	WP_073817556.1	RusA family crossover junction endodeoxyribonuclease	-
C5B83_RS00590	104178..104999	+	822	WP_000762933.1	antitermination protein	-
C5B83_RS00595	105226..105466	+	241	Protein_116	hypothetical protein	-
C5B83_RS00600	105574..106632	+	1059	WP_000935541.1	site-specific DNA-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	83360..140464	57104

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96334 WP_000813254.1 NZ_CP026834:101778-101933 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96334 NZ_CP026834:101778-101933 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGCTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96334 NZ_CP026834:c101766-101708 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin