Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4373194..4373451 Replicon chromosome
Accession NZ_CP026832
Organism Shigella dysenteriae strain ATCC 49346

Toxin (Protein)


Gene name hokA Uniprot ID Q31V67
Locus tag C5B81_RS23040 Protein ID WP_001135724.1
Coordinates 4373299..4373451 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 4373194..4373248 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B81_RS23010 4368703..4368933 - 231 Protein_4434 IS4 family transposase -
C5B81_RS23015 4368937..4369146 - 210 Protein_4435 IS66 family insertion sequence element accessory protein TnpB -
C5B81_RS23020 4369143..4369499 - 357 WP_000239757.1 transposase -
C5B81_RS23025 4369650..4370792 + 1143 Protein_4437 IS4-like element IS4 family transposase -
- 4373194..4373248 - 55 - - Antitoxin
C5B81_RS23040 4373299..4373451 + 153 WP_001135724.1 type I toxin-antitoxin system toxin HokA Toxin
C5B81_RS26960 4373440..4373499 - 60 WP_212732943.1 hypothetical protein -
C5B81_RS23045 4373630..4373842 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
C5B81_RS23050 4374123..4374413 - 291 WP_005045913.1 HTH-type transcriptional regulator -
C5B81_RS23060 4375622..4376332 + 711 WP_004987320.1 DUF3053 domain-containing protein -
C5B81_RS23065 4376382..4377356 - 975 WP_000805034.1 glyoxylate/hydroxypyruvate reductase GhrB -
C5B81_RS23070 4377460..4378047 - 588 WP_000747616.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 4369143..4375045 5902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5868.09 Da        Isoelectric Point: 7.7173

>T96327 WP_001135724.1 NZ_CP026832:4373299-4373451 [Shigella dysenteriae]
MPQKYGLLSLIVICFTLLFFTWMVRDSLCELHIKQGRYELAAFLACNLKE

Download         Length: 153 bp

>T96327 NZ_CP026832:4373299-4373451 [Shigella dysenteriae]
ATGCCGCAAAAATACGGATTACTTTCATTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGGTAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGCGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT96327 NZ_CP026832:c4373248-4373194 [Shigella dysenteriae]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q31V67

Antitoxin

Download structure file

References