Detailed information of TA system TA096310

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1977113..1977338
• Replicon: chromosome
• Accession: NZ_CP026832
• Organism: Shigella dysenteriae strain ATCC 49346

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C5B81_RS10290
• Protein ID: WP_000813254.1
• Coordinates: 1977183..1977338 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1977113..1977171 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C5B81_RS10235	1972445..1972741	+	297	WP_001266130.1	DUF4406 domain-containing protein	-
C5B81_RS10240	1972738..1973199	+	462	WP_001209470.1	sigma-E factor regulatory protein RseB domain-containing protein	-
C5B81_RS10245	1973177..1973533	+	357	WP_000403782.1	hypothetical protein	-
C5B81_RS10250	1973629..1973811	+	183	WP_001224665.1	hypothetical protein	-
C5B81_RS26115	1973804..1973980	+	177	WP_000753053.1	hypothetical protein	-
C5B81_RS10255	1973977..1974336	+	360	WP_001289986.1	hypothetical protein	-
C5B81_RS10260	1974337..1974552	+	216	WP_000510389.1	hypothetical protein	-
C5B81_RS10265	1974554..1974772	+	219	WP_001142588.1	DUF4014 family protein	-
C5B81_RS10270	1974774..1975037	+	264	WP_000224216.1	hypothetical protein	-
C5B81_RS10275	1975048..1975215	+	168	WP_000207997.1	hypothetical protein	-
C5B81_RS10280	1975415..1976643	+	1229	WP_088895425.1	IS3-like element IS2 family transposase	-
C5B81_RS10285	1976628..1976891	+	264	WP_242412557.1	hypothetical protein	-
-	1977113..1977171	-	59	-	-	Antitoxin
C5B81_RS10290	1977183..1977338	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
C5B81_RS10295	1977555..1977806	+	252	WP_000980988.1	protein Rem	-
C5B81_RS10300	1977873..1978151	+	279	WP_032335658.1	hypothetical protein	-
C5B81_RS10305	1978153..1979199	+	1047	WP_001265091.1	DUF968 domain-containing protein	-
C5B81_RS10310	1979212..1979586	+	375	WP_000904094.1	RusA family crossover junction endodeoxyribonuclease	-
C5B81_RS10315	1979583..1980404	+	822	WP_000762933.1	antitermination protein	-
C5B81_RS10320	1980631..1980871	+	241	Protein_1976	hypothetical protein	-
C5B81_RS10325	1980979..1982037	+	1059	WP_134801094.1	site-specific DNA-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1944979..2015775	70796

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96310 WP_000813254.1 NZ_CP026832:1977183-1977338 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96310 NZ_CP026832:1977183-1977338 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGCTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96310 NZ_CP026832:c1977171-1977113 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin