Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2089061..2089623 Replicon chromosome
Accession NZ_CP026831
Organism Shigella dysenteriae strain ATCC 12039

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag C1P71_RS11835 Protein ID WP_000605676.1
Coordinates 2089061..2089339 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag C1P71_RS11840 Protein ID WP_000781370.1
Coordinates 2089339..2089623 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P71_RS11810 (2084831) 2084831..2085262 - 432 WP_000152305.1 peroxiredoxin OsmC -
C1P71_RS11815 (2085607) 2085607..2085822 + 216 WP_128880559.1 biofilm-dependent modulation protein -
C1P71_RS11820 (2085924) 2085924..2085992 + 69 Protein_2044 stationary-phase-induced ribosome-associated protein -
C1P71_RS11825 (2086034) 2086034..2087731 + 1698 WP_000433462.1 malate dehydrogenase -
C1P71_RS11830 (2087865) 2087865..2088875 + 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
C1P71_RS11835 (2089061) 2089061..2089339 + 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1P71_RS11840 (2089339) 2089339..2089623 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
C1P71_RS11845 (2089675) 2089675..2090328 - 654 WP_000045646.1 formate dehydrogenase-N subunit gamma -
C1P71_RS11850 (2090321) 2090321..2091205 - 885 WP_001240582.1 formate dehydrogenase N subunit beta -
C1P71_RS11855 (2091218) 2091218..2094265 - 3048 WP_011310214.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T96297 WP_000605676.1 NZ_CP026831:2089061-2089339 [Shigella dysenteriae]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

>T96297 NZ_CP026831:2089061-2089339 [Shigella dysenteriae]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACACAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCAAGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ACCCGTTAAGCGGTGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATATATACTGGATTACGAGGACTATCACTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT96297 WP_000781370.1 NZ_CP026831:2089339-2089623 [Shigella dysenteriae]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp

>AT96297 NZ_CP026831:2089339-2089623 [Shigella dysenteriae]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGTCGATTGCTAACCGGAAAAGCAGCTTTGACACCAGAAATGGCGA
TTAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAACGCCTGGAGTCTGGCAGAGGCAGAA
AAAACGGTGGATGTGTCGCGATTACGCCGTCTGGTTACGCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References