96294

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1588468..1588970 Replicon chromosome
Accession NZ_CP026831
Organism Shigella dysenteriae strain ATCC 12039

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag C1P71_RS09155 Protein ID WP_000767829.1
Coordinates 1588716..1588970 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag C1P71_RS09150 Protein ID WP_128880351.1
Coordinates 1588468..1588719 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P71_RS09125 (1583647) 1583647..1584714 - 1068 WP_000080087.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
C1P71_RS09130 (1584714) 1584714..1585784 - 1071 WP_128880349.1 histidinol-phosphate transaminase -
C1P71_RS09135 (1585781) 1585781..1587085 - 1305 WP_128880350.1 histidinol dehydrogenase -
C1P71_RS09140 (1587091) 1587091..1587990 - 900 WP_000131756.1 ATP phosphoribosyltransferase -
C1P71_RS09145 (1588136) 1588136..1588186 - 51 WP_001364200.1 his operon leader peptide -
C1P71_RS09150 (1588468) 1588468..1588719 + 252 WP_128880351.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C1P71_RS09155 (1588716) 1588716..1588970 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
C1P71_RS09160 (1589053) 1589053..1589877 + 825 WP_128880352.1 SDR family oxidoreductase -
C1P71_RS09165 (1589923) 1589923..1590852 + 930 WP_128880353.1 LysR substrate-binding domain-containing protein -
C1P71_RS09170 (1591066) 1591066..1591128 + 63 WP_097415165.1 membrane protein YoeI -
C1P71_RS09175 (1591118) 1591118..1592476 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
C1P71_RS09180 (1592655) 1592655..1593713 + 1059 WP_128880354.1 thiosulfate utilization transporter TsuA/YeeE -
C1P71_RS09185 (1593727) 1593727..1593954 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T96294 WP_000767829.1 NZ_CP026831:1588716-1588970 [Shigella dysenteriae]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T96294 NZ_CP026831:1588716-1588970 [Shigella dysenteriae]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTAGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9334.61 Da        Isoelectric Point: 4.7954

>AT96294 WP_128880351.1 NZ_CP026831:1588468-1588719 [Shigella dysenteriae]
MRTINYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT96294 NZ_CP026831:1588468-1588719 [Shigella dysenteriae]
ATGCGTACAATTAACTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References