Detailed information of TA system TA096278

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3450866..3451091
• Replicon: chromosome
• Accession: NZ_CP026828
• Organism: Shigella dysenteriae strain ATCC 12037

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P70_RS18150
• Protein ID: WP_000813254.1
• Coordinates: 3450866..3451021 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3451033..3451091 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P70_RS18115	3446166..3447224	-	1059	WP_134807195.1	site-specific DNA-methyltransferase	-
C1P70_RS18120	3447333..3447573	-	241	Protein_3493	hypothetical protein	-
C1P70_RS18125	3447800..3448621	-	822	WP_000762933.1	antitermination protein	-
C1P70_RS18130	3448618..3448992	-	375	WP_000904114.1	RusA family crossover junction endodeoxyribonuclease	-
C1P70_RS18135	3449005..3450051	-	1047	WP_001265091.1	DUF968 domain-containing protein	-
C1P70_RS26840	3450053..3450331	-	279	WP_134807196.1	hypothetical protein	-
C1P70_RS18145	3450398..3450649	-	252	WP_000980988.1	protein Rem	-
C1P70_RS18150	3450866..3451021	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3451033..3451091	+	59	-	-	Antitoxin
C1P70_RS18155	3451313..3451576	-	264	WP_242412557.1	hypothetical protein	-
C1P70_RS18165	3452990..3453157	-	168	WP_000207997.1	hypothetical protein	-
C1P70_RS18170	3453225..3454381	+	1157	WP_094110543.1	IS3-like element IS600 family transposase	-
C1P70_RS18175	3454427..3454909	+	483	Protein_3504	tyrosine-type recombinase/integrase	-
C1P70_RS18180	3454955..3455593	-	639	WP_000737224.1	outer membrane protein OmpW	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3411558..3458029	46471

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96278 WP_000813254.1 NZ_CP026828:c3451021-3450866 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96278 NZ_CP026828:c3451021-3450866 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGCTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96278 NZ_CP026828:3451033-3451091 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin