96266

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2589308..2589810 Replicon chromosome
Accession NZ_CP026828
Organism Shigella dysenteriae strain ATCC 12037

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag C1P70_RS13195 Protein ID WP_000767829.1
Coordinates 2589556..2589810 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag C1P70_RS13190 Protein ID WP_001259255.1
Coordinates 2589308..2589559 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P70_RS13165 (2584485) 2584485..2585552 - 1068 WP_134807073.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
C1P70_RS13170 (2585552) 2585552..2586622 - 1071 WP_134807074.1 histidinol-phosphate transaminase -
C1P70_RS13175 (2586619) 2586619..2587923 - 1305 WP_001515511.1 histidinol dehydrogenase -
C1P70_RS13180 (2587929) 2587929..2588828 - 900 WP_134807075.1 ATP phosphoribosyltransferase -
C1P70_RS13185 (2588974) 2588974..2589024 - 51 WP_001364200.1 his operon leader peptide -
C1P70_RS13190 (2589308) 2589308..2589559 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C1P70_RS13195 (2589556) 2589556..2589810 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
C1P70_RS13200 (2589893) 2589893..2590717 + 825 WP_000754752.1 SDR family oxidoreductase -
C1P70_RS13205 (2590763) 2590763..2591692 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
C1P70_RS13210 (2591907) 2591907..2591969 + 63 WP_010723108.1 membrane protein YoeI -
C1P70_RS13215 (2591959) 2591959..2593317 + 1359 WP_097325566.1 putrescine/proton symporter PlaP -
C1P70_RS13220 (2593496) 2593496..2594554 + 1059 WP_134807076.1 thiosulfate utilization transporter TsuA/YeeE -
C1P70_RS13225 (2594568) 2594568..2594795 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T96266 WP_000767829.1 NZ_CP026828:2589556-2589810 [Shigella dysenteriae]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T96266 NZ_CP026828:2589556-2589810 [Shigella dysenteriae]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT96266 WP_001259255.1 NZ_CP026828:2589308-2589559 [Shigella dysenteriae]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT96266 NZ_CP026828:2589308-2589559 [Shigella dysenteriae]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References