Detailed information of TA system TA096263

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1596343..1596601
• Replicon: chromosome
• Accession: NZ_CP026828
• Organism: Shigella dysenteriae strain ATCC 12037

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: C1P70_RS08240
• Protein ID: WP_000809168.1
• Coordinates: 1596343..1596495 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1596544..1596601 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P70_RS08215	1591546..1591722	-	177	Protein_1576	DUF2541 family protein	-
C1P70_RS08220	1591745..1592442	-	698	Protein_1577	IS1 family transposase	-
C1P70_RS08225	1592497..1592727	-	231	Protein_1578	DUF2541 family protein	-
C1P70_RS08230	1593104..1595020	+	1917	WP_000516135.1	molecular chaperone DnaK	-
C1P70_RS08235	1595109..1596239	+	1131	WP_001118467.1	molecular chaperone DnaJ	-
C1P70_RS08240	1596343..1596495	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	1596544..1596601	+	58	-	-	Antitoxin
C1P70_RS08245	1597081..1598247	+	1167	WP_000681369.1	Na+/H+ antiporter NhaA	-
C1P70_RS08250	1598313..1599212	+	900	WP_001300855.1	transcriptional activator NhaR	-
C1P70_RS08255	1599250..1599684	-	435	Protein_1584	fimbrial family protein	-
C1P70_RS08260	1599775..1601003	+	1229	WP_088895425.1	IS3-like element IS2 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1591745..1592122	377

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T96263 WP_000809168.1 NZ_CP026828:c1596495-1596343 [Shigella dysenteriae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T96263 NZ_CP026828:c1596495-1596343 [Shigella dysenteriae]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT96263 NZ_CP026828:1596544-1596601 [Shigella dysenteriae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin