Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 616159..616416 Replicon chromosome
Accession NZ_CP026828
Organism Shigella dysenteriae strain ATCC 12037

Toxin (Protein)


Gene name hokA Uniprot ID Q31V67
Locus tag C1P70_RS03215 Protein ID WP_001135724.1
Coordinates 616159..616311 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 616362..616416 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P70_RS03185 611563..612150 + 588 WP_000747616.1 OmpA family lipoprotein -
C1P70_RS03190 612254..613228 + 975 WP_000805034.1 glyoxylate/hydroxypyruvate reductase GhrB -
C1P70_RS03195 613278..613988 - 711 WP_004987320.1 DUF3053 domain-containing protein -
C1P70_RS03200 614245..614942 + 698 WP_252988899.1 IS1-like element IS1SD family transposase -
C1P70_RS03205 615197..615487 + 291 WP_004987407.1 HTH-type transcriptional regulator -
C1P70_RS03210 615768..615980 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
C1P70_RS26475 616111..616170 + 60 WP_212732943.1 hypothetical protein -
C1P70_RS03215 616159..616311 - 153 WP_001135724.1 type I toxin-antitoxin system toxin HokA Toxin
- 616362..616416 + 55 - - Antitoxin
C1P70_RS03220 616575..617272 + 698 WP_225322336.1 IS1 family transposase -
C1P70_RS03225 617576..618804 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -
C1P70_RS03230 618818..619960 - 1143 Protein_630 IS4 family transposase -
C1P70_RS03235 620111..620467 + 357 WP_000239757.1 transposase -
C1P70_RS03240 620464..620673 + 210 Protein_632 IS66 family insertion sequence element accessory protein TnpB -
C1P70_RS03245 620677..620907 + 231 Protein_633 IS4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 614565..620467 5902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5868.09 Da        Isoelectric Point: 7.7173

>T96261 WP_001135724.1 NZ_CP026828:c616311-616159 [Shigella dysenteriae]
MPQKYGLLSLIVICFTLLFFTWMVRDSLCELHIKQGRYELAAFLACNLKE

Download         Length: 153 bp

>T96261 NZ_CP026828:c616311-616159 [Shigella dysenteriae]
ATGCCGCAAAAATACGGATTACTTTCATTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGGTAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGCGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT96261 NZ_CP026828:616362-616416 [Shigella dysenteriae]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q31V67

Antitoxin

Download structure file

References