Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2972650..2972908 Replicon chromosome
Accession NZ_CP026827
Organism Shigella dysenteriae strain ATCC 12021

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag C5B75_RS16935 Protein ID WP_000809168.1
Coordinates 2972756..2972908 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2972650..2972707 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B75_RS16910 2968582..2968785 + 204 WP_128875364.1 hypothetical protein -
C5B75_RS16915 2968739..2969029 + 291 Protein_3023 fimbrial protein -
C5B75_RS16920 2969042..2970001 + 960 WP_000871653.1 hypothetical protein -
C5B75_RS16925 2970039..2970938 - 900 WP_001300855.1 transcriptional activator NhaR -
C5B75_RS16930 2971004..2972170 - 1167 WP_000681368.1 Na+/H+ antiporter NhaA -
- 2972650..2972707 - 58 - - Antitoxin
C5B75_RS16935 2972756..2972908 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
C5B75_RS16940 2972952..2974142 - 1191 WP_128875526.1 IS4-like element ISEc60 family transposase -
C5B75_RS16945 2974316..2975446 - 1131 WP_001118464.1 molecular chaperone DnaJ -
C5B75_RS16950 2975535..2977451 - 1917 WP_000516135.1 molecular chaperone DnaK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2967986..2974142 6156


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T96252 WP_000809168.1 NZ_CP026827:2972756-2972908 [Shigella dysenteriae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T96252 NZ_CP026827:2972756-2972908 [Shigella dysenteriae]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT96252 NZ_CP026827:c2972707-2972650 [Shigella dysenteriae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References