Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4528550..4528808 Replicon chromosome
Accession NZ_CP026819
Organism Shigella dysenteriae strain 96-265

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag C1P77_RS24435 Protein ID WP_000809168.1
Coordinates 4528550..4528702 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4528751..4528808 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P77_RS24410 4523768..4523944 - 177 Protein_4608 DUF2541 family protein -
C1P77_RS24420 4524719..4524949 - 231 Protein_4610 DUF2541 family protein -
C1P77_RS24425 4525326..4527242 + 1917 WP_000516135.1 molecular chaperone DnaK -
C1P77_RS24430 4527331..4528446 + 1116 WP_001118451.1 molecular chaperone DnaJ -
C1P77_RS24435 4528550..4528702 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 4528751..4528808 + 58 - - Antitoxin
C1P77_RS24440 4529288..4530454 + 1167 WP_000681373.1 Na+/H+ antiporter NhaA -
C1P77_RS24445 4530520..4531419 + 900 WP_001300855.1 transcriptional activator NhaR -
C1P77_RS24450 4531457..4531891 - 435 Protein_4616 fimbrial family protein -
C1P77_RS24455 4531982..4532729 + 748 Protein_4617 IS3-like element IS2 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4523967..4524470 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T96227 WP_000809168.1 NZ_CP026819:c4528702-4528550 [Shigella dysenteriae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T96227 NZ_CP026819:c4528702-4528550 [Shigella dysenteriae]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT96227 NZ_CP026819:4528751-4528808 [Shigella dysenteriae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References