Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 3532395..3532652 Replicon chromosome
Accession NZ_CP026819
Organism Shigella dysenteriae strain 96-265

Toxin (Protein)


Gene name hokA Uniprot ID Q31V67
Locus tag C1P77_RS19410 Protein ID WP_001135724.1
Coordinates 3532500..3532652 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 3532395..3532449 (-)

Genomic Context


C1P77_RS19395C1P77_RS19410C1P77_RS19430C1P77_RS19380C1P77_RS19385C1P77_RS19390--C1P77_RS27365C1P77_RS19415C1P77_RS19420C1P77_RS19435C1P77_RS19440
Location: 3528851..3529993 (1143 bp)
Type: Others
Protein ID: Protein_3657
Location: 3532500..3532652 (153 bp)
Type: Toxin
Protein ID: WP_001135724.1
Location: 3534823..3535533 (711 bp)
Type: Others
Protein ID: WP_005045940.1
Location: 3527904..3528134 (231 bp)
Type: Others
Protein ID: Protein_3654
Location: 3528138..3528347 (210 bp)
Type: Others
Protein ID: Protein_3655
Location: 3528344..3528700 (357 bp)
Type: Others
Protein ID: WP_000239757.1
Location: 3532395..3532449 (55 bp)
Type: Antitoxin
Protein ID: -
Location: 3532641..3532700 (60 bp)
Type: Others
Protein ID: WP_212732943.1
Location: 3532831..3533043 (213 bp)
Type: Others
Protein ID: WP_000014594.1
Location: 3533324..3533614 (291 bp)
Type: Others
Protein ID: WP_005045913.1
Location: 3535583..3536557 (975 bp)
Type: Others
Protein ID: WP_000805034.1
Location: 3536661..3537248 (588 bp)
Type: Others
Protein ID: WP_000747616.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C1P77_RS193803527904..3528134-231Protein_3654IS4 family transposase-
C1P77_RS193853528138..3528347-210Protein_3655IS66 family insertion sequence element accessory protein TnpB-
C1P77_RS193903528344..3528700-357WP_000239757.1transposase-
C1P77_RS193953528851..3529993+1143Protein_3657IS4-like element IS4 family transposase-
-3532395..3532449-55--Antitoxin
C1P77_RS194103532500..3532652+153WP_001135724.1type I toxin-antitoxin system toxin HokAToxin
C1P77_RS273653532641..3532700-60WP_212732943.1hypothetical protein-
C1P77_RS194153532831..3533043-213WP_000014594.1RNA chaperone/antiterminator CspA-
C1P77_RS194203533324..3533614-291WP_005045913.1HTH-type transcriptional regulator-
C1P77_RS194303534823..3535533+711WP_005045940.1DUF3053 domain-containing protein-
C1P77_RS194353535583..3536557-975WP_000805034.1glyoxylate/hydroxypyruvate reductase GhrB-
C1P77_RS194403536661..3537248-588WP_000747616.1OmpA family lipoprotein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIScluster/Tn--3528344..35342465902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-46)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5868.09 Da        Isoelectric Point: 7.7173

>T96224 WP_001135724.1 NZ_CP026819:3532500-3532652 [Shigella dysenteriae]
MPQKYGLLSLIVICFTLLFFTWMVRDSLCELHIKQGRYELAAFLACNLKE

Download         Length: 153 bp

>T96224 NZ_CP026819:3532500-3532652 [Shigella dysenteriae]
ATGCCGCAAAAATACGGATTACTTTCATTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGGTAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGCGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT96224 NZ_CP026819:c3532449-3532395 [Shigella dysenteriae]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBQ31V67


Antitoxin

Download structure file

References