Detailed information of TA system TA096206

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1105741..1105966
• Replicon: chromosome
• Accession: NZ_CP026819
• Organism: Shigella dysenteriae strain 96-265

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P77_RS06545
• Protein ID: WP_000813254.1
• Coordinates: 1105811..1105966 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1105741..1105799 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P77_RS06490	1101073..1101369	+	297	WP_001266130.1	DUF4406 domain-containing protein	-
C1P77_RS06495	1101366..1101827	+	462	WP_001209470.1	sigma-E factor regulatory protein RseB domain-containing protein	-
C1P77_RS06500	1101805..1102161	+	357	WP_000403782.1	hypothetical protein	-
C1P77_RS06505	1102257..1102439	+	183	WP_001224665.1	hypothetical protein	-
C1P77_RS27030	1102432..1102608	+	177	WP_000753053.1	hypothetical protein	-
C1P77_RS06510	1102605..1102964	+	360	WP_001289986.1	hypothetical protein	-
C1P77_RS06515	1102965..1103180	+	216	WP_000510389.1	hypothetical protein	-
C1P77_RS06520	1103182..1103400	+	219	WP_001142588.1	DUF4014 family protein	-
C1P77_RS06525	1103402..1103665	+	264	WP_000224216.1	hypothetical protein	-
C1P77_RS06530	1103676..1103843	+	168	WP_000207997.1	hypothetical protein	-
C1P77_RS06535	1104043..1105271	+	1229	WP_088895425.1	IS3-like element IS2 family transposase	-
C1P77_RS06540	1105256..1105519	+	264	WP_242412557.1	hypothetical protein	-
-	1105741..1105799	-	59	-	-	Antitoxin
C1P77_RS06545	1105811..1105966	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
C1P77_RS06550	1106183..1106434	+	252	WP_000980988.1	protein Rem	-
C1P77_RS06555	1106501..1106779	+	279	WP_032335658.1	hypothetical protein	-
C1P77_RS06560	1106781..1107827	+	1047	WP_001265099.1	DUF968 domain-containing protein	-
C1P77_RS06565	1107840..1108214	+	375	WP_000904094.1	RusA family crossover junction endodeoxyribonuclease	-
C1P77_RS06570	1108211..1109032	+	822	WP_069661440.1	antitermination protein	-
C1P77_RS06575	1109259..1109499	+	241	Protein_1164	hypothetical protein	-
C1P77_RS06580	1109607..1110665	+	1059	WP_000935541.1	site-specific DNA-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1086615..1144499	57884

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96206 WP_000813254.1 NZ_CP026819:1105811-1105966 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96206 NZ_CP026819:1105811-1105966 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGCTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96206 NZ_CP026819:c1105799-1105741 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin