Detailed information of TA system TA096183

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1754510..1754735
• Replicon: chromosome
• Accession: NZ_CP026815
• Organism: Shigella dysenteriae strain 93-119

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P76_RS09030
• Protein ID: WP_000813254.1
• Coordinates: 1754580..1754735 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1754510..1754568 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P76_RS08985	1749873..1750295	+	423	WP_001151146.1	DUF977 family protein	-
C1P76_RS08990	1750292..1750597	+	306	WP_001266147.1	DUF4406 domain-containing protein	-
C1P76_RS08995	1750584..1751039	+	456	WP_000335375.1	ead/Ea22-like family protein	-
C1P76_RS09000	1751089..1752627	-	1539	WP_000099181.1	IS66-like element ISEc22 family transposase	-
C1P76_RS09005	1752676..1753023	-	348	WP_000612610.1	IS66 family insertion sequence element accessory protein TnpB	-
C1P76_RS09010	1753020..1753400	-	381	WP_001333468.1	transposase	-
C1P76_RS09015	1753512..1753928	+	417	WP_005069274.1	hypothetical protein	-
-	1754510..1754568	-	59	-	-	Antitoxin
C1P76_RS09030	1754580..1754735	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
C1P76_RS09040	1754903..1755181	+	279	WP_000929754.1	hypothetical protein	-
C1P76_RS09045	1755183..1755932	+	750	Protein_1749	hypothetical protein	-
C1P76_RS09055	1755982..1756910	-	929	Protein_1750	IS3-like element IS600 family transposase	-
C1P76_RS27610	1757679..1757747	+	69	Protein_1752	phage tail protein	-
C1P76_RS09065	1757750..1758295	+	546	WP_000902849.1	tail fiber assembly protein	-
C1P76_RS09070	1758319..1759587	+	1269	Protein_1754	prophage tail fiber N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ipaH9.8	1721515..1787705	66190
	-	inside	IScluster/Tn	-	-	1722172..1757303	35131

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96183 WP_000813254.1 NZ_CP026815:1754580-1754735 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96183 NZ_CP026815:1754580-1754735 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96183 NZ_CP026815:c1754568-1754510 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin