96182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1693921..1694423 Replicon chromosome
Accession NZ_CP026815
Organism Shigella dysenteriae strain 93-119

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag C1P76_RS08660 Protein ID WP_000767829.1
Coordinates 1694169..1694423 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag C1P76_RS08655 Protein ID WP_001259255.1
Coordinates 1693921..1694172 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P76_RS08625 (1689099) 1689099..1690166 - 1068 WP_000080132.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
C1P76_RS08630 (1690166) 1690166..1691236 - 1071 WP_000108951.1 histidinol-phosphate transaminase -
C1P76_RS08635 (1691233) 1691233..1692537 - 1305 WP_005032012.1 histidinol dehydrogenase -
C1P76_RS08640 (1692543) 1692543..1693442 - 900 WP_000131769.1 ATP phosphoribosyltransferase -
C1P76_RS08645 (1693588) 1693588..1693638 - 51 WP_001364200.1 his operon leader peptide -
C1P76_RS08655 (1693921) 1693921..1694172 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C1P76_RS08660 (1694169) 1694169..1694423 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
C1P76_RS08665 (1694506) 1694506..1695329 + 824 Protein_1682 SDR family oxidoreductase -
C1P76_RS08670 (1695375) 1695375..1696166 + 792 Protein_1683 LysR substrate-binding domain-containing protein -
C1P76_RS08680 (1697012) 1697012..1698240 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -
C1P76_RS08685 (1698265) 1698265..1698417 + 153 Protein_1686 LysR family transcriptional regulator -
C1P76_RS08690 (1698631) 1698631..1698693 + 63 WP_010723108.1 membrane protein YoeI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T96182 WP_000767829.1 NZ_CP026815:1694169-1694423 [Shigella dysenteriae]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T96182 NZ_CP026815:1694169-1694423 [Shigella dysenteriae]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATAGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT96182 WP_001259255.1 NZ_CP026815:1693921-1694172 [Shigella dysenteriae]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT96182 NZ_CP026815:1693921-1694172 [Shigella dysenteriae]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References