Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1693921..1694423 Replicon chromosome
Accession NZ_CP026815
Organism Shigella dysenteriae strain 93-119

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag C1P76_RS08660 Protein ID WP_000767829.1
Coordinates 1694169..1694423 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag C1P76_RS08655 Protein ID WP_001259255.1
Coordinates 1693921..1694172 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P76_RS08625 (1689099) 1689099..1690166 - 1068 WP_000080132.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
C1P76_RS08630 (1690166) 1690166..1691236 - 1071 WP_000108951.1 histidinol-phosphate transaminase -
C1P76_RS08635 (1691233) 1691233..1692537 - 1305 WP_005032012.1 histidinol dehydrogenase -
C1P76_RS08640 (1692543) 1692543..1693442 - 900 WP_000131769.1 ATP phosphoribosyltransferase -
C1P76_RS08645 (1693588) 1693588..1693638 - 51 WP_001364200.1 his operon leader peptide -
C1P76_RS08655 (1693921) 1693921..1694172 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C1P76_RS08660 (1694169) 1694169..1694423 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
C1P76_RS08665 (1694506) 1694506..1695329 + 824 Protein_1682 SDR family oxidoreductase -
C1P76_RS08670 (1695375) 1695375..1696166 + 792 Protein_1683 LysR substrate-binding domain-containing protein -
C1P76_RS08680 (1697012) 1697012..1698240 + 1229 WP_088895425.1 IS3-like element IS2 family transposase -
C1P76_RS08685 (1698265) 1698265..1698417 + 153 Protein_1686 LysR family transcriptional regulator -
C1P76_RS08690 (1698631) 1698631..1698693 + 63 WP_010723108.1 membrane protein YoeI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T96182 WP_000767829.1 NZ_CP026815:1694169-1694423 [Shigella dysenteriae]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T96182 NZ_CP026815:1694169-1694423 [Shigella dysenteriae]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATAGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT96182 WP_001259255.1 NZ_CP026815:1693921-1694172 [Shigella dysenteriae]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT96182 NZ_CP026815:1693921-1694172 [Shigella dysenteriae]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References