Detailed information of TA system TA096120

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3834141..3834398
• Replicon: chromosome
• Accession: NZ_CP026807
• Organism: Shigella dysenteriae strain 204/96

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: Q31V67
• Locus tag: C1P75_RS20300
• Protein ID: WP_001135724.1
• Coordinates: 3834141..3834293 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3834344..3834398 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P75_RS20270	3829545..3830132	+	588	WP_000747616.1	OmpA family lipoprotein	-
C1P75_RS20275	3830236..3831210	+	975	WP_000805034.1	glyoxylate/hydroxypyruvate reductase GhrB	-
C1P75_RS20280	3831260..3831970	-	711	WP_005045940.1	DUF3053 domain-containing protein	-
C1P75_RS20285	3832227..3832924	+	698	WP_134795416.1	IS1-like element IS1SD family transposase	-
C1P75_RS20290	3833179..3833469	+	291	WP_005045913.1	HTH-type transcriptional regulator	-
C1P75_RS20295	3833750..3833962	+	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
C1P75_RS27950	3834093..3834152	+	60	WP_212732943.1	hypothetical protein	-
C1P75_RS20300	3834141..3834293	-	153	WP_001135724.1	type I toxin-antitoxin system toxin HokA	Toxin
-	3834344..3834398	+	55	-	-	Antitoxin
C1P75_RS20305	3834557..3835254	+	698	WP_094106546.1	IS1 family transposase	-
C1P75_RS20310	3835558..3836786	+	1229	WP_088895425.1	IS3-like element IS2 family transposase	-
C1P75_RS20315	3836800..3837942	-	1143	Protein_3903	IS4-like element IS4 family transposase	-
C1P75_RS20320	3838093..3838449	+	357	WP_000239757.1	transposase	-
C1P75_RS20325	3838446..3838655	+	210	Protein_3905	IS66 family insertion sequence element accessory protein TnpB	-
C1P75_RS20330	3838659..3838889	+	231	Protein_3906	IS4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	3832547..3838449	5902

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5868.09 Da
• Isoelectric Point: 7.7173

>T96120 WP_001135724.1 NZ_CP026807:c3834293-3834141 [Shigella dysenteriae]
MPQKYGLLSLIVICFTLLFFTWMVRDSLCELHIKQGRYELAAFLACNLKE

Nucleotide

• Length: 153 bp

>T96120 NZ_CP026807:c3834293-3834141 [Shigella dysenteriae]
ATGCCGCAAAAATACGGATTACTTTCATTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGGTAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGCGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin

Nucleotide

• Length: 55 bp

>AT96120 NZ_CP026807:3834344-3834398 [Shigella dysenteriae]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: Q31V67

Antitoxin