Detailed information of TA system TA096118

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2836921..2837179
• Replicon: chromosome
• Accession: NZ_CP026807
• Organism: Shigella dysenteriae strain 204/96

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: C1P75_RS15255
• Protein ID: WP_000809168.1
• Coordinates: 2837027..2837179 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2836921..2836978 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P75_RS15235	2832318..2832752	+	435	Protein_2941	fimbrial family protein	-
C1P75_RS15240	2832790..2833689	-	900	WP_001300855.1	transcriptional activator NhaR	-
C1P75_RS15245	2833755..2834921	-	1167	WP_000681373.1	Na+/H+ antiporter NhaA	-
C1P75_RS15250	2835204..2836331	+	1128	WP_001063816.1	IS110-like element ISSso6 family transposase	-
-	2836921..2836978	-	58	-	-	Antitoxin
C1P75_RS15255	2837027..2837179	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
C1P75_RS15260	2837283..2838398	-	1116	WP_001118451.1	molecular chaperone DnaJ	-
C1P75_RS15265	2838487..2840403	-	1917	WP_000516135.1	molecular chaperone DnaK	-
C1P75_RS15270	2840780..2841010	+	231	Protein_2948	DUF2541 family protein	-
C1P75_RS15275	2841065..2841762	+	698	WP_237161507.1	IS1 family transposase	-
C1P75_RS15280	2841785..2841961	+	177	Protein_2950	DUF2541 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2828855..2841762	12907

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T96118 WP_000809168.1 NZ_CP026807:2837027-2837179 [Shigella dysenteriae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T96118 NZ_CP026807:2837027-2837179 [Shigella dysenteriae]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT96118 NZ_CP026807:c2836978-2836921 [Shigella dysenteriae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin