Detailed information of TA system TA096114

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1514866..1515091
• Replicon: chromosome
• Accession: NZ_CP026807
• Organism: Shigella dysenteriae strain 204/96

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P75_RS08220
• Protein ID: WP_000813254.1
• Coordinates: 1514866..1515021 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1515033..1515091 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P75_RS08185	1510167..1511225	-	1059	WP_000935541.1	site-specific DNA-methyltransferase	-
C1P75_RS08190	1511333..1511573	-	241	Protein_1592	hypothetical protein	-
C1P75_RS08195	1511800..1512621	-	822	WP_069661440.1	antitermination protein	-
C1P75_RS08200	1512618..1512992	-	375	WP_000904094.1	RusA family crossover junction endodeoxyribonuclease	-
C1P75_RS08205	1513005..1514051	-	1047	WP_001265099.1	DUF968 domain-containing protein	-
C1P75_RS08210	1514053..1514331	-	279	WP_032335658.1	hypothetical protein	-
C1P75_RS08215	1514398..1514649	-	252	WP_000980988.1	protein Rem	-
C1P75_RS08220	1514866..1515021	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1515033..1515091	+	59	-	-	Antitoxin
C1P75_RS08225	1515313..1515546	-	234	WP_000350274.1	hypothetical protein	-
C1P75_RS08235	1516989..1517156	-	168	WP_000207997.1	hypothetical protein	-
C1P75_RS08240	1517167..1517430	-	264	WP_000224216.1	hypothetical protein	-
C1P75_RS08245	1517432..1517650	-	219	WP_001142588.1	DUF4014 family protein	-
C1P75_RS08250	1517652..1517867	-	216	WP_000510389.1	hypothetical protein	-
C1P75_RS08255	1517868..1518227	-	360	WP_001289986.1	hypothetical protein	-
C1P75_RS27675	1518224..1518400	-	177	WP_000753053.1	hypothetical protein	-
C1P75_RS08260	1518393..1518575	-	183	WP_001224665.1	hypothetical protein	-
C1P75_RS08265	1518671..1519027	-	357	WP_000403782.1	hypothetical protein	-
C1P75_RS08270	1519005..1519466	-	462	WP_001209470.1	sigma-E factor regulatory protein RseB domain-containing protein	-
C1P75_RS08275	1519463..1519759	-	297	WP_001266130.1	DUF4406 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	galU	1476333..1558035	81702

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96114 WP_000813254.1 NZ_CP026807:c1515021-1514866 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96114 NZ_CP026807:c1515021-1514866 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGCTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96114 NZ_CP026807:1515033-1515091 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin