Detailed information of TA system TA096104

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 705551..705776
• Replicon: chromosome
• Accession: NZ_CP026807
• Organism: Shigella dysenteriae strain 204/96

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P75_RS03640
• Protein ID: WP_000813254.1
• Coordinates: 705621..705776 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	705551..705609 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P75_RS03595	700914..701336	+	423	WP_001151146.1	DUF977 family protein	-
C1P75_RS03600	701333..701638	+	306	WP_001266147.1	DUF4406 domain-containing protein	-
C1P75_RS03605	701625..702080	+	456	WP_000335375.1	ead/Ea22-like family protein	-
C1P75_RS03610	702130..703668	-	1539	WP_000099181.1	IS66-like element ISEc22 family transposase	-
C1P75_RS03615	703717..704064	-	348	WP_000612610.1	IS66 family insertion sequence element accessory protein TnpB	-
C1P75_RS03620	704061..704441	-	381	WP_001333468.1	transposase	-
C1P75_RS03625	704553..704969	+	417	WP_005069274.1	hypothetical protein	-
-	705551..705609	-	59	-	-	Antitoxin
C1P75_RS03640	705621..705776	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
C1P75_RS03650	705944..706222	+	279	WP_000929754.1	hypothetical protein	-
C1P75_RS03655	706224..706973	+	750	Protein_700	hypothetical protein	-
C1P75_RS03665	707023..707951	-	929	Protein_701	IS3-like element IS600 family transposase	-
C1P75_RS27475	708720..708788	+	69	Protein_703	phage tail protein	-
C1P75_RS03675	708791..709336	+	546	WP_000902849.1	tail fiber assembly protein	-
C1P75_RS03680	709360..710629	+	1270	Protein_705	prophage tail fiber N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ipaH9.8	660176..735006	74830
	-	inside	IScluster/Tn	-	-	673210..708344	35134

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96104 WP_000813254.1 NZ_CP026807:705621-705776 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96104 NZ_CP026807:705621-705776 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96104 NZ_CP026807:c705609-705551 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin