Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3654711..3654969 Replicon chromosome
Accession NZ_CP026805
Organism Shigella dysenteriae strain 2017C-4522

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag C1P73_RS19330 Protein ID WP_000809168.1
Coordinates 3654711..3654863 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3654912..3654969 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P73_RS19305 3649929..3650105 - 177 Protein_3719 DUF2541 family protein -
C1P73_RS19315 3650880..3651110 - 231 Protein_3721 DUF2541 family protein -
C1P73_RS19320 3651487..3653403 + 1917 WP_000516135.1 molecular chaperone DnaK -
C1P73_RS19325 3653492..3654607 + 1116 WP_001118451.1 molecular chaperone DnaJ -
C1P73_RS19330 3654711..3654863 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3654912..3654969 + 58 - - Antitoxin
C1P73_RS19335 3655559..3656686 - 1128 WP_001063816.1 IS110-like element ISSso6 family transposase -
C1P73_RS19340 3656969..3658135 + 1167 WP_000681373.1 Na+/H+ antiporter NhaA -
C1P73_RS19345 3658201..3659100 + 900 WP_171765938.1 transcriptional activator NhaR -
C1P73_RS19350 3659138..3659377 - 240 Protein_3728 fimbrial family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 3650128..3663036 12908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T96097 WP_000809168.1 NZ_CP026805:c3654863-3654711 [Shigella dysenteriae]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T96097 NZ_CP026805:c3654863-3654711 [Shigella dysenteriae]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT96097 NZ_CP026805:3654912-3654969 [Shigella dysenteriae]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References