Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2696157..2696414 Replicon chromosome
Accession NZ_CP026805
Organism Shigella dysenteriae strain 2017C-4522

Toxin (Protein)


Gene name hokA Uniprot ID Q31V67
Locus tag C1P73_RS14520 Protein ID WP_001135724.1
Coordinates 2696262..2696414 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokA
Locus tag -
Coordinates 2696157..2696211 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P73_RS14490 2691667..2691897 - 231 Protein_2806 IS4 family transposase -
C1P73_RS14495 2691901..2692110 - 210 Protein_2807 IS66 family insertion sequence element accessory protein TnpB -
C1P73_RS14500 2692107..2692463 - 357 WP_000239757.1 transposase -
C1P73_RS14505 2692614..2693756 + 1143 Protein_2809 IS4-like element IS4 family transposase -
- 2696157..2696211 - 55 - - Antitoxin
C1P73_RS14520 2696262..2696414 + 153 WP_001135724.1 type I toxin-antitoxin system toxin HokA Toxin
C1P73_RS25610 2696403..2696462 - 60 WP_212732943.1 hypothetical protein -
C1P73_RS14525 2696593..2696805 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
C1P73_RS14530 2697086..2697376 - 291 WP_005045913.1 HTH-type transcriptional regulator -
C1P73_RS14540 2698585..2699295 + 711 WP_004987320.1 DUF3053 domain-containing protein -
C1P73_RS14545 2699345..2700319 - 975 WP_000805034.1 glyoxylate/hydroxypyruvate reductase GhrB -
C1P73_RS14550 2700423..2701010 - 588 WP_000747616.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 2692107..2698008 5901


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5868.09 Da        Isoelectric Point: 7.7173

>T96094 WP_001135724.1 NZ_CP026805:2696262-2696414 [Shigella dysenteriae]
MPQKYGLLSLIVICFTLLFFTWMVRDSLCELHIKQGRYELAAFLACNLKE

Download         Length: 153 bp

>T96094 NZ_CP026805:2696262-2696414 [Shigella dysenteriae]
ATGCCGCAAAAATACGGATTACTTTCATTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGGTAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGGGCGTTATGAGCTGGCGGCATTTTTAGCCTGCAATTTAAAAGAGTAA

Antitoxin


Download         Length: 55 bp

>AT96094 NZ_CP026805:c2696211-2696157 [Shigella dysenteriae]
GTTCAGGCATAGGGTAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q31V67

Antitoxin

Download structure file

References