Detailed information of TA system TA096087

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1016719..1016944
• Replicon: chromosome
• Accession: NZ_CP026805
• Organism: Shigella dysenteriae strain 2017C-4522

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P73_RS05795
• Protein ID: WP_000813254.1
• Coordinates: 1016719..1016874 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1016886..1016944 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P73_RS05755	1011867..1013135	-	1269	Protein_1121	prophage tail fiber N-terminal domain-containing protein	-
C1P73_RS05760	1013159..1013704	-	546	WP_000902849.1	tail fiber assembly protein	-
C1P73_RS25430	1013707..1013775	-	69	Protein_1123	phage tail protein	-
C1P73_RS05765	1013831..1014528	+	698	WP_134795416.1	IS1-like element IS1SD family transposase	-
C1P73_RS05770	1014544..1015472	+	929	Protein_1125	IS3-like element IS600 family transposase	-
C1P73_RS05780	1015522..1016271	-	750	Protein_1126	hypothetical protein	-
C1P73_RS05785	1016273..1016551	-	279	WP_000929754.1	hypothetical protein	-
C1P73_RS05795	1016719..1016874	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1016886..1016944	+	59	-	-	Antitoxin
C1P73_RS05810	1017525..1017941	-	417	WP_005069274.1	hypothetical protein	-
C1P73_RS05815	1018053..1018274	+	222	WP_134796774.1	transposase	-
C1P73_RS05820	1018271..1018432	+	162	WP_000171090.1	hypothetical protein	-
C1P73_RS05825	1018429..1018776	+	348	WP_000612610.1	IS66 family insertion sequence element accessory protein TnpB	-
C1P73_RS05830	1018825..1020363	+	1539	WP_000099181.1	IS66-like element ISEc22 family transposase	-
C1P73_RS05835	1020413..1020868	-	456	WP_000335375.1	ead/Ea22-like family protein	-
C1P73_RS05840	1020855..1021160	-	306	WP_001266147.1	DUF4406 domain-containing protein	-
C1P73_RS05845	1021157..1021579	-	423	WP_001151146.1	DUF977 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ipaH9.8	982432..1070349	87917
	-	inside	IScluster/Tn	-	ipaH9.8	1001122..1025402	24280

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96087 WP_000813254.1 NZ_CP026805:c1016874-1016719 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96087 NZ_CP026805:c1016874-1016719 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96087 NZ_CP026805:1016886-1016944 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin