Detailed information of TA system TA096077

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 307525..307750
• Replicon: chromosome
• Accession: NZ_CP026805
• Organism: Shigella dysenteriae strain 2017C-4522

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P73_RS01765
• Protein ID: WP_000813254.1
• Coordinates: 307595..307750 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	307525..307583 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P73_RS01710	302858..303154	+	297	WP_001266130.1	DUF4406 domain-containing protein	-
C1P73_RS01715	303151..303612	+	462	WP_001209470.1	sigma-E factor regulatory protein RseB domain-containing protein	-
C1P73_RS01720	303590..303946	+	357	WP_000403782.1	hypothetical protein	-
C1P73_RS01725	304042..304224	+	183	WP_001224665.1	hypothetical protein	-
C1P73_RS24945	304217..304393	+	177	WP_000753053.1	hypothetical protein	-
C1P73_RS01730	304390..304749	+	360	WP_001289986.1	hypothetical protein	-
C1P73_RS01735	304750..304965	+	216	WP_000510387.1	hypothetical protein	-
C1P73_RS01740	304967..305185	+	219	WP_001142588.1	DUF4014 family protein	-
C1P73_RS01745	305187..305450	+	264	WP_000224216.1	hypothetical protein	-
C1P73_RS01750	305461..305628	+	168	WP_000207997.1	hypothetical protein	-
C1P73_RS01755	305827..307055	+	1229	WP_167544911.1	IS3-like element IS2 family transposase	-
C1P73_RS01760	307070..307303	+	234	WP_000350274.1	hypothetical protein	-
-	307525..307583	-	59	-	-	Antitoxin
C1P73_RS01765	307595..307750	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
C1P73_RS01770	307967..308218	+	252	WP_000980988.1	protein Rem	-
C1P73_RS01775	308285..308563	+	279	WP_032335658.1	hypothetical protein	-
C1P73_RS01780	308565..309611	+	1047	WP_001265091.1	DUF968 domain-containing protein	-
C1P73_RS01785	309624..309998	+	375	WP_073817556.1	RusA family crossover junction endodeoxyribonuclease	-
C1P73_RS01790	309995..310816	+	822	WP_000762933.1	antitermination protein	-
C1P73_RS01795	311043..311283	+	241	Protein_346	hypothetical protein	-
C1P73_RS01800	311391..312449	+	1059	WP_000935541.1	site-specific DNA-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	291670..346272	54602

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T96077 WP_000813254.1 NZ_CP026805:307595-307750 [Shigella dysenteriae]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T96077 NZ_CP026805:307595-307750 [Shigella dysenteriae]
ATGAAGCAGCAAAAGGCGATGCTAATCGCCCTGATCGTCATCTGTTTAACCGTCATTGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT96077 NZ_CP026805:c307583-307525 [Shigella dysenteriae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACGTGTGTAGAGCATAGATATGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin