Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1134113..1134641 Replicon chromosome
Accession NZ_CP026803
Organism Shigella flexneri strain 89-141

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag C1P88_RS05695 Protein ID WP_005080041.1
Coordinates 1134113..1134343 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C1P88_RS05700 Protein ID WP_000147079.1
Coordinates 1134333..1134641 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P88_RS05670 (1130462) 1130462..1131340 - 879 WP_000988185.1 ATP-binding protein -
C1P88_RS05675 (1131351) 1131351..1132259 - 909 WP_001247839.1 hypothetical protein -
C1P88_RS05680 (1132246) 1132246..1132479 - 234 WP_000618005.1 hypothetical protein -
C1P88_RS05685 (1132476) 1132476..1133336 - 861 WP_001300485.1 Rha family phage regulatory protein -
C1P88_RS05690 (1133333) 1133333..1134100 - 768 WP_094185463.1 ash family protein -
C1P88_RS05695 (1134113) 1134113..1134343 + 231 WP_005080041.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C1P88_RS05700 (1134333) 1134333..1134641 + 309 WP_000147079.1 helix-turn-helix transcriptional regulator Antitoxin
C1P88_RS05705 (1134663) 1134663..1134836 - 174 WP_094185464.1 DUF4222 domain-containing protein -
C1P88_RS05710 (1134856) 1134856..1135266 - 411 Protein_1094 DNA-binding protein -
C1P88_RS05715 (1135329) 1135329..1136485 + 1157 WP_086020934.1 IS3-like element IS600 family transposase -
C1P88_RS05720 (1136527) 1136527..1137311 + 785 Protein_1096 DUF4132 domain-containing protein -
C1P88_RS05725 (1137372) 1137372..1137779 + 408 WP_000636931.1 hypothetical protein -
C1P88_RS05730 (1138321) 1138321..1139409 + 1089 WP_005075761.1 MoxR family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(5-70)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-94)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8682.15 Da        Isoelectric Point: 10.5308

>T96058 WP_005080041.1 NZ_CP026803:1134113-1134343 [Shigella flexneri]
MKVYGSNLGEPHTSAFGDGLFELRIKGSDGIARVFYCTLTGKRIIMLHSFIKKTQKTPPAERKKAETRMKEVKHDW

Download         Length: 231 bp

>T96058 NZ_CP026803:1134113-1134343 [Shigella flexneri]
ATGAAGGTATACGGCAGCAATCTCGGAGAACCTCACACCAGCGCCTTTGGTGATGGGCTTTTTGAGCTTCGGATTAAAGG
CAGCGATGGCATTGCCCGCGTTTTTTACTGCACACTGACAGGGAAGCGCATCATCATGCTGCACAGCTTCATCAAGAAAA
CTCAAAAAACTCCACCAGCTGAGCGTAAAAAAGCTGAAACCAGAATGAAGGAGGTTAAGCATGACTGGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11166.89 Da        Isoelectric Point: 8.5840

>AT96058 WP_000147079.1 NZ_CP026803:1134333-1134641 [Shigella flexneri]
MTGKRNPPIMTHDEMAAKWMDDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGVSG
PSFATLKKFARATGKKLQIRFV

Download         Length: 309 bp

>AT96058 NZ_CP026803:1134333-1134641 [Shigella flexneri]
ATGACTGGTAAACGTAACCCACCAATCATGACACACGATGAAATGGCAGCTAAATGGATGGATGACCCGGCTTTTAAAGC
AGAATACGACGCCATCGCCGACGAGTTCGCACTGCTTGATGAAATGCTGGCCGCACGCAAAGAAGCTGGTCTCACCCAGG
CTGAAGTTGCTGAACGCATGGGTACCAAAGCAACCGCCATCACCAGAATGGAAAGCAATCTTGCCTCAGGTGTCAGCGGA
CCATCATTTGCCACACTGAAAAAATTTGCACGCGCAACAGGGAAAAAACTCCAGATCCGCTTCGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References