96036

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 748755..749257 Replicon chromosome
Accession NZ_CP026802
Organism Shigella sonnei strain ATCC 29930

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag C1P89_RS03850 Protein ID WP_000767829.1
Coordinates 749003..749257 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag C1P89_RS03845 Protein ID WP_001259255.1
Coordinates 748755..749006 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P89_RS03820 (743933) 743933..745000 - 1068 WP_000080086.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
C1P89_RS03825 (745000) 745000..746070 - 1071 WP_000108977.1 histidinol-phosphate transaminase -
C1P89_RS03830 (746067) 746067..747371 - 1305 WP_001462576.1 histidinol dehydrogenase -
C1P89_RS03835 (747377) 747377..748276 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
C1P89_RS03840 (748422) 748422..748472 - 51 WP_001364200.1 his operon leader peptide -
C1P89_RS03845 (748755) 748755..749006 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C1P89_RS03850 (749003) 749003..749257 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
C1P89_RS03855 (749340) 749340..750164 + 825 WP_000754737.1 SDR family oxidoreductase -
C1P89_RS03860 (750210) 750210..751139 + 930 WP_000811606.1 LysR substrate-binding domain-containing protein -
C1P89_RS03865 (751354) 751354..751416 + 63 WP_010723108.1 membrane protein YoeI -
C1P89_RS03870 (751406) 751406..752764 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
C1P89_RS03875 (752943) 752943..754001 + 1059 WP_000492295.1 thiosulfate utilization transporter TsuA/YeeE -
C1P89_RS03880 (754015) 754015..754242 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T96036 WP_000767829.1 NZ_CP026802:749003-749257 [Shigella sonnei]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T96036 NZ_CP026802:749003-749257 [Shigella sonnei]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT96036 WP_001259255.1 NZ_CP026802:748755-749006 [Shigella sonnei]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT96036 NZ_CP026802:748755-749006 [Shigella sonnei]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References