96008

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2543469..2543971 Replicon chromosome
Accession NZ_CP026795
Organism Shigella boydii strain ATCC BAA-1247

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag C5B80_RS13655 Protein ID WP_000767829.1
Coordinates 2543717..2543971 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag C5B80_RS13650 Protein ID WP_001259255.1
Coordinates 2543469..2543720 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5B80_RS13625 2538647..2539714 - 1068 WP_000080095.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
C5B80_RS13630 2539714..2540784 - 1071 WP_000108980.1 histidinol-phosphate transaminase -
C5B80_RS13635 2540781..2542085 - 1305 WP_039060143.1 histidinol dehydrogenase -
C5B80_RS13640 2542091..2542990 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
C5B80_RS13645 2543136..2543186 - 51 WP_001364200.1 his operon leader peptide -
C5B80_RS13650 2543469..2543720 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
C5B80_RS13655 2543717..2543971 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
C5B80_RS13660 2544054..2544878 + 825 WP_000754747.1 SDR family oxidoreductase -
C5B80_RS13665 2544924..2545853 + 930 WP_039059232.1 LysR family transcriptional regulator -
C5B80_RS13670 2546068..2546130 + 63 WP_010723108.1 membrane protein YoeI -
C5B80_RS13675 2546120..2547478 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
C5B80_RS13680 2547657..2548617 + 961 Protein_2605 YeeE/YedE family protein -
C5B80_RS13685 2548631..2548858 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T96008 WP_000767829.1 NZ_CP026795:2543717-2543971 [Shigella boydii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T96008 NZ_CP026795:2543717-2543971 [Shigella boydii]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT96008 WP_001259255.1 NZ_CP026795:2543469-2543720 [Shigella boydii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT96008 NZ_CP026795:2543469-2543720 [Shigella boydii]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCTAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References