Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4699560..4699785 Replicon chromosome
Accession NZ_CP026793
Organism Shigella flexneri strain 74-1170

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag C1P81_RS24165 Protein ID WP_000813254.1
Coordinates 4699560..4699715 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 4699727..4699785 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P81_RS24100 4694872..4695222 - 351 WP_005049241.1 IS66 family insertion sequence element accessory protein TnpB -
C1P81_RS24105 4695219..4695893 - 675 WP_004967157.1 IS66-like element accessory protein TnpA -
C1P81_RS24110 4695992..4696207 - 216 WP_000839572.1 class II holin family protein -
C1P81_RS24140 4697003..4697691 - 689 Protein_4626 bacteriophage antitermination protein Q -
C1P81_RS24145 4697688..4698053 - 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
C1P81_RS24150 4698054..4699112 - 1059 WP_001265248.1 DUF968 domain-containing protein -
C1P81_RS24155 4699114..4699392 - 279 WP_011069426.1 hypothetical protein -
C1P81_RS24165 4699560..4699715 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
- 4699727..4699785 + 59 - - Antitoxin
C1P81_RS24180 4700367..4700783 - 417 WP_005069274.1 hypothetical protein -
C1P81_RS24185 4700810..4700950 + 141 Protein_4632 DUF4224 domain-containing protein -
C1P81_RS24190 4700950..4702000 + 1051 Protein_4633 tyrosine-type recombinase/integrase -
C1P81_RS24200 4702211..4703008 + 798 WP_001325918.1 DgsA anti-repressor MtfA -
C1P81_RS24210 4703346..4704608 + 1263 Protein_4635 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 4682160..4732963 50803


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T95988 WP_000813254.1 NZ_CP026793:c4699715-4699560 [Shigella flexneri]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T95988 NZ_CP026793:c4699715-4699560 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT95988 NZ_CP026793:4699727-4699785 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References