95967

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3731991..3732444 Replicon chromosome
Accession NZ_CP026792
Organism Shigella flexneri strain 61-4982

Toxin (Protein)


Gene name itaT Uniprot ID A0A822PL35
Locus tag C1P80_RS19630 Protein ID WP_005053055.1
Coordinates 3732286..3732444 (+) Length 53 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A5H0K0
Locus tag C1P80_RS19625 Protein ID WP_005053053.1
Coordinates 3731991..3732302 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P80_RS19600 3727461..3727958 + 498 Protein_3646 COX aromatic rich motif-containing protein -
C1P80_RS19605 3727980..3729971 + 1992 Protein_3647 cytochrome o ubiquinol oxidase subunit I -
C1P80_RS19610 3729961..3730575 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
C1P80_RS19615 3730575..3730904 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
C1P80_RS19620 3730916..3731806 + 891 WP_000971346.1 heme o synthase -
C1P80_RS19625 3731991..3732302 + 312 WP_005053053.1 DUF1778 domain-containing protein Antitoxin
C1P80_RS19630 3732286..3732444 + 159 WP_005053055.1 hypothetical protein Toxin
C1P80_RS19635 3732437..3732836 + 400 Protein_3653 GNAT family N-acetyltransferase -
C1P80_RS19640 3732884..3733581 - 698 Protein_3654 IS1 family transposase -
C1P80_RS19645 3733732..3735885 + 2154 WP_005060811.1 SEL1-like repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 3732884..3733387 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(15-97)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 5914.82 Da        Isoelectric Point: 6.9172

>T95967 WP_005053055.1 NZ_CP026792:3732286-3732444 [Shigella flexneri]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRATRIAKEKCA

Download         Length: 159 bp

>T95967 NZ_CP026792:3732286-3732444 [Shigella flexneri]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCTACGCGCATCGCTAAAGAAAAGTGTGCGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11394.07 Da        Isoelectric Point: 10.3388

>AT95967 WP_005053053.1 NZ_CP026792:3731991-3732302 [Shigella flexneri]
MPGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT95967 NZ_CP026792:3731991-3732302 [Shigella flexneri]
ATGCCTGGAAAAACAGCCGCTCTATACGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A822PL35

Antitoxin

Source ID Structure
AlphaFold DB A5H0K0

References