Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2071589..2071814 Replicon chromosome
Accession NZ_CP026792
Organism Shigella flexneri strain 61-4982

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag C1P80_RS10720 Protein ID WP_000813254.1
Coordinates 2071659..2071814 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2071589..2071647 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P80_RS10675 2066766..2068028 - 1263 Protein_1959 tyrosine-type recombinase/integrase -
C1P80_RS10685 2068366..2069163 - 798 WP_001325918.1 DgsA anti-repressor MtfA -
C1P80_RS10695 2069399..2070424 - 1026 WP_000533619.1 tyrosine-type recombinase/integrase -
C1P80_RS10700 2070424..2070564 - 141 Protein_1962 DUF4224 domain-containing protein -
C1P80_RS10705 2070591..2071007 + 417 WP_005069274.1 hypothetical protein -
- 2071589..2071647 - 59 - - Antitoxin
C1P80_RS10720 2071659..2071814 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
C1P80_RS10730 2071982..2072260 + 279 WP_011069426.1 hypothetical protein -
C1P80_RS10735 2072262..2073320 + 1059 WP_001265248.1 DUF968 domain-containing protein -
C1P80_RS10740 2073321..2073686 + 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
C1P80_RS10745 2073683..2074366 + 684 WP_005049343.1 antiterminator -
C1P80_RS10775 2075167..2075382 + 216 WP_000839572.1 class II holin family protein -
C1P80_RS10780 2075481..2075672 + 192 Protein_1970 helix-turn-helix domain-containing protein -
C1P80_RS10785 2075684..2076381 - 698 Protein_1971 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 2035850..2093996 58146


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T95960 WP_000813254.1 NZ_CP026792:2071659-2071814 [Shigella flexneri]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T95960 NZ_CP026792:2071659-2071814 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT95960 NZ_CP026792:c2071647-2071589 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References