Detailed information of TA system TA095942

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 943160..943385
• Replicon: chromosome
• Accession: NZ_CP026788
• Organism: Shigella flexneri 2a strain ATCC 29903

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P79_RS05205
• Protein ID: WP_000813254.1
• Coordinates: 943160..943315 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	943327..943385 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P79_RS05165	938286..938768	-	483	WP_000068107.1	ORF6N domain-containing protein	-
C1P79_RS05175	940057..940230	-	174	WP_000504450.1	hypothetical protein	-
C1P79_RS05180	940383..940937	-	555	WP_000640143.1	DUF1133 family protein	-
C1P79_RS05185	940934..941224	-	291	WP_000228038.1	DUF1364 domain-containing protein	-
C1P79_RS05190	941224..941823	-	600	WP_000940329.1	DUF1367 family protein	-
C1P79_RS05195	941957..942654	+	698	WP_225620329.1	IS1 family transposase	-
C1P79_RS05205	943160..943315	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	943327..943385	+	59	-	-	Antitoxin
C1P79_RS05210	943770..944135	-	366	WP_000610655.1	DUF551 domain-containing protein	-
C1P79_RS05215	944135..944800	-	666	WP_000208062.1	hypothetical protein	-
C1P79_RS05220	944797..945162	-	366	WP_001229298.1	HNH endonuclease signature motif containing protein	-
C1P79_RS05225	945164..945382	-	219	WP_000256998.1	DUF4014 family protein	-
C1P79_RS05230	945475..945831	-	357	WP_005048249.1	hypothetical protein	-
C1P79_RS05235	945889..946311	-	423	WP_001118168.1	DUF977 family protein	-
C1P79_RS05240	946326..947072	-	747	WP_000788996.1	ATP-binding protein	-
C1P79_RS26165	947218..947387	-	170	Protein_988	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	sitABCD	ipaH9.8	889553..956417	66864

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T95942 WP_000813254.1 NZ_CP026788:c943315-943160 [Shigella flexneri 2a]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T95942 NZ_CP026788:c943315-943160 [Shigella flexneri 2a]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT95942 NZ_CP026788:943327-943385 [Shigella flexneri 2a]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin