Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 250777..251002 Replicon chromosome
Accession NZ_CP026788
Organism Shigella flexneri 2a strain ATCC 29903

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag C1P79_RS01295 Protein ID WP_000813254.1
Coordinates 250847..251002 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 250777..250835 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P79_RS01250 245954..247216 - 1263 Protein_234 tyrosine-type recombinase/integrase -
C1P79_RS01260 247554..248351 - 798 WP_001325918.1 DgsA anti-repressor MtfA -
C1P79_RS01270 248562..249612 - 1051 Protein_236 tyrosine-type recombinase/integrase -
C1P79_RS01275 249612..249752 - 141 Protein_237 DUF4224 domain-containing protein -
C1P79_RS01280 249779..250195 + 417 WP_005069274.1 hypothetical protein -
- 250777..250835 - 59 - - Antitoxin
C1P79_RS01295 250847..251002 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
C1P79_RS01305 251170..251448 + 279 WP_011069426.1 hypothetical protein -
C1P79_RS01310 251450..252508 + 1059 WP_001265248.1 DUF968 domain-containing protein -
C1P79_RS01315 252509..252874 + 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
C1P79_RS01320 252871..253559 + 689 Protein_243 bacteriophage antitermination protein Q -
C1P79_RS01350 254355..254570 + 216 WP_000839572.1 class II holin family protein -
C1P79_RS01355 254669..255343 + 675 WP_004967157.1 IS66-like element accessory protein TnpA -
C1P79_RS01360 255340..255690 + 351 WP_005049241.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 206932..282852 75920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T95931 WP_000813254.1 NZ_CP026788:250847-251002 [Shigella flexneri 2a]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T95931 NZ_CP026788:250847-251002 [Shigella flexneri 2a]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT95931 NZ_CP026788:c250835-250777 [Shigella flexneri 2a]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References