Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2443864..2444405 Replicon chromosome
Accession NZ_CP026777
Organism Shigella dysenteriae strain 69-3818

Toxin (Protein)


Gene name yafQ Uniprot ID Q32JN3
Locus tag C5C01_RS13160 Protein ID WP_000615980.1
Coordinates 2443864..2444142 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q32JN2
Locus tag C5C01_RS13165 Protein ID WP_000729709.1
Coordinates 2444145..2444405 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5C01_RS13145 2441446..2442024 + 579 WP_005020694.1 D-sedoheptulose 7-phosphate isomerase -
C5C01_RS13150 2442230..2442997 + 768 WP_000333379.1 class II glutamine amidotransferase -
C5C01_RS13155 2442968..2443708 - 741 WP_001225679.1 murein L,D-transpeptidase -
C5C01_RS13160 2443864..2444142 - 279 WP_000615980.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
C5C01_RS13165 2444145..2444405 - 261 WP_000729709.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
C5C01_RS13170 2444615..2445364 + 750 WP_011378552.1 C40 family peptidase -
C5C01_RS13180 2446315..2446632 + 318 Protein_2467 transposase -
C5C01_RS13185 2446689..2447383 + 695 WP_134805583.1 IS1 family transposase -
C5C01_RS13190 2447614..2447958 + 345 Protein_2469 fimbria/pilus periplasmic chaperone -
C5C01_RS13195 2448013..2448710 + 698 Protein_2470 IS1 family transposase -
C5C01_RS13205 2448999..2449211 - 213 Protein_2471 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T95833 WP_000615980.1 NZ_CP026777:c2444142-2443864 [Shigella dysenteriae]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T95833 NZ_CP026777:c2444142-2443864 [Shigella dysenteriae]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAGG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGCTCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9333.73 Da        Isoelectric Point: 5.8129

>AT95833 WP_000729709.1 NZ_CP026777:c2444405-2444145 [Shigella dysenteriae]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT95833 NZ_CP026777:c2444405-2444145 [Shigella dysenteriae]
ATGGCTGCAAATGCATTTGTTCGTGCCCGAATCGATGAGGATTTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGGTGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090NH48

Antitoxin

Source ID Structure
AlphaFold DB A0A829FY17

References