Detailed information of TA system TA095814

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 903591..903816
• Replicon: chromosome
• Accession: NZ_CP026776
• Organism: Shigella flexneri strain 98-3193

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P84_RS04960
• Protein ID: WP_000813254.1
• Coordinates: 903591..903746 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	903758..903816 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P84_RS04920	898717..899199	-	483	WP_000068107.1	ORF6N domain-containing protein	-
C1P84_RS04930	900488..900661	-	174	WP_000504450.1	hypothetical protein	-
C1P84_RS04935	900814..901368	-	555	WP_000640143.1	DUF1133 family protein	-
C1P84_RS04940	901365..901655	-	291	WP_000228038.1	DUF1364 domain-containing protein	-
C1P84_RS04945	901655..902254	-	600	WP_000940329.1	DUF1367 family protein	-
C1P84_RS04950	902388..903085	+	698	WP_227804319.1	IS1 family transposase	-
C1P84_RS04960	903591..903746	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	903758..903816	+	59	-	-	Antitoxin
C1P84_RS04965	904201..904566	-	366	WP_000610655.1	DUF551 domain-containing protein	-
C1P84_RS04970	904566..905231	-	666	WP_000208062.1	hypothetical protein	-
C1P84_RS04975	905228..905593	-	366	WP_001229298.1	HNH endonuclease signature motif containing protein	-
C1P84_RS04980	905595..905813	-	219	WP_000256998.1	DUF4014 family protein	-
C1P84_RS04985	905906..906262	-	357	WP_005048249.1	hypothetical protein	-
C1P84_RS04990	906320..906742	-	423	WP_001118167.1	DUF977 family protein	-
C1P84_RS04995	906757..907500	-	744	WP_000788999.1	ATP-binding protein	-
C1P84_RS23615	907646..907815	-	170	Protein_941	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ipaH9.8	874539..915397	40858

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T95814 WP_000813254.1 NZ_CP026776:c903746-903591 [Shigella flexneri]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T95814 NZ_CP026776:c903746-903591 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT95814 NZ_CP026776:903758-903816 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin