Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 267123..267348 Replicon chromosome
Accession NZ_CP026776
Organism Shigella flexneri strain 98-3193

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag C1P84_RS01410 Protein ID WP_000813254.1
Coordinates 267193..267348 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 267123..267181 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P84_RS01365 262310..263572 - 1263 Protein_258 tyrosine-type recombinase/integrase -
C1P84_RS01375 263910..264707 - 798 WP_024260703.1 DgsA anti-repressor MtfA -
C1P84_RS01385 264918..265958 - 1041 WP_005096324.1 tyrosine-type recombinase/integrase -
C1P84_RS01390 265958..266098 - 141 Protein_261 DUF4224 domain-containing protein -
C1P84_RS01395 266125..266541 + 417 WP_005069274.1 hypothetical protein -
- 267123..267181 - 59 - - Antitoxin
C1P84_RS01410 267193..267348 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
C1P84_RS01420 267516..267794 + 279 WP_011069426.1 hypothetical protein -
C1P84_RS01425 267796..268854 + 1059 WP_001265248.1 DUF968 domain-containing protein -
C1P84_RS01430 268855..269220 + 366 WP_000140017.1 RusA family crossover junction endodeoxyribonuclease -
C1P84_RS01435 269217..269905 + 689 Protein_267 bacteriophage antitermination protein Q -
C1P84_RS01465 270701..270916 + 216 WP_000839572.1 class II holin family protein -
C1P84_RS01470 271015..271689 + 675 WP_004967157.1 IS66-like element accessory protein TnpA -
C1P84_RS01475 271686..272036 + 351 WP_005049241.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 231694..293618 61924


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T95803 WP_000813254.1 NZ_CP026776:267193-267348 [Shigella flexneri]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T95803 NZ_CP026776:267193-267348 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT95803 NZ_CP026776:c267181-267123 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References