Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 2119724..2120418 Replicon chromosome
Accession NZ_CP026768
Organism Shigella flexneri Y strain 93-3063

Toxin (Protein)


Gene name yafO Uniprot ID Q0T7Q5
Locus tag C1P87_RS11210 Protein ID WP_001263491.1
Coordinates 2119724..2120122 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID Q0T7Q4
Locus tag C1P87_RS11215 Protein ID WP_000554759.1
Coordinates 2120125..2120418 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P87_RS11185 (2115063) 2115063..2115521 - 459 WP_001291990.1 xanthine phosphoribosyltransferase -
C1P87_RS11190 (2115783) 2115783..2117240 + 1458 WP_001293009.1 cytosol nonspecific dipeptidase -
C1P87_RS11195 (2117297) 2117297..2117857 - 561 Protein_2160 peptide chain release factor H -
C1P87_RS11200 (2117973) 2117973..2119016 - 1044 WP_005060486.1 RNA ligase RtcB family protein -
C1P87_RS11205 (2119262) 2119262..2119714 - 453 WP_001059861.1 GNAT family N-acetyltransferase -
C1P87_RS11210 (2119724) 2119724..2120122 - 399 WP_001263491.1 type II toxin-antitoxin system mRNA interferase toxin YafO Toxin
C1P87_RS11215 (2120125) 2120125..2120418 - 294 WP_000554759.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
C1P87_RS11220 (2120470) 2120470..2121525 - 1056 WP_001226172.1 DNA polymerase IV -
C1P87_RS11225 (2121596) 2121596..2122381 - 786 WP_000207561.1 putative lateral flagellar export/assembly protein LafU -
C1P87_RS11230 (2122353) 2122353..2124065 + 1713 Protein_2167 flagellar biosynthesis protein FlhA -
C1P87_RS11235 (2124282) 2124282..2124779 - 498 WP_000006251.1 REP-associated tyrosine transposase RayT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15457.86 Da        Isoelectric Point: 8.0949

>T95771 WP_001263491.1 NZ_CP026768:c2120122-2119724 [Shigella flexneri Y]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T95771 NZ_CP026768:c2120122-2119724 [Shigella flexneri Y]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11232.82 Da        Isoelectric Point: 7.0153

>AT95771 WP_000554759.1 NZ_CP026768:c2120418-2120125 [Shigella flexneri Y]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
KQYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT95771 NZ_CP026768:c2120418-2120125 [Shigella flexneri Y]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
AGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTTCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
AAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TPK7

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TR46

References