Detailed information of TA system TA095768

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1029629..1029854
• Replicon: chromosome
• Accession: NZ_CP026768
• Organism: Shigella flexneri Y strain 93-3063

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P87_RS05535
• Protein ID: WP_000813254.1
• Coordinates: 1029629..1029784 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1029796..1029854 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P87_RS05495	1024755..1025237	-	483	WP_000068107.1	ORF6N domain-containing protein	-
C1P87_RS05505	1026526..1026711	-	186	WP_005049799.1	hypothetical protein	-
C1P87_RS05510	1026852..1027406	-	555	WP_000640143.1	DUF1133 family protein	-
C1P87_RS05515	1027403..1027693	-	291	WP_000228038.1	DUF1364 domain-containing protein	-
C1P87_RS05520	1027693..1028292	-	600	WP_000940329.1	DUF1367 family protein	-
C1P87_RS26065	1028195..1028527	-	333	WP_171764399.1	hypothetical protein	-
C1P87_RS05525	1028426..1029123	+	698	WP_252988570.1	IS1 family transposase	-
C1P87_RS05535	1029629..1029784	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	1029796..1029854	+	59	-	-	Antitoxin
C1P87_RS05540	1030239..1030604	-	366	WP_000610655.1	DUF551 domain-containing protein	-
C1P87_RS05545	1030604..1031269	-	666	WP_000208062.1	hypothetical protein	-
C1P87_RS05550	1031266..1031631	-	366	WP_001229298.1	HNH endonuclease signature motif containing protein	-
C1P87_RS05555	1031633..1031851	-	219	WP_000256998.1	DUF4014 family protein	-
C1P87_RS05560	1031944..1032300	-	357	WP_005048249.1	hypothetical protein	-
C1P87_RS05570	1033625..1034047	-	423	WP_001118167.1	DUF977 family protein	-
C1P87_RS05575	1034062..1034808	-	747	WP_128861108.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	sitABCD	ipaH9.8	977677..1040367	62690
	-	inside	IScluster/Tn	sitABCD	-	1002779..1037882	35103

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T95768 WP_000813254.1 NZ_CP026768:c1029784-1029629 [Shigella flexneri Y]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T95768 NZ_CP026768:c1029784-1029629 [Shigella flexneri Y]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT95768 NZ_CP026768:1029796-1029854 [Shigella flexneri Y]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin