Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 368624..368849 Replicon chromosome
Accession NZ_CP026768
Organism Shigella flexneri Y strain 93-3063

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag C1P87_RS01810 Protein ID WP_000813254.1
Coordinates 368694..368849 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 368624..368682 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C1P87_RS01765 363801..365063 - 1263 Protein_342 tyrosine-type recombinase/integrase -
C1P87_RS01775 365401..366198 - 798 WP_001325918.1 DgsA anti-repressor MtfA -
C1P87_RS01785 366409..367459 - 1051 Protein_344 tyrosine-type recombinase/integrase -
C1P87_RS01790 367459..367599 - 141 Protein_345 DUF4224 domain-containing protein -
C1P87_RS01795 367626..368042 + 417 WP_005069274.1 hypothetical protein -
- 368624..368682 - 59 - - Antitoxin
C1P87_RS01810 368694..368849 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
C1P87_RS01820 369017..369295 + 279 WP_011069426.1 hypothetical protein -
C1P87_RS01825 369297..370355 + 1059 WP_001265248.1 DUF968 domain-containing protein -
C1P87_RS01830 370356..370721 + 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
C1P87_RS01835 370718..371406 + 689 Protein_351 bacteriophage antitermination protein Q -
C1P87_RS01865 372202..372417 + 216 WP_000839572.1 class II holin family protein -
C1P87_RS01870 372516..372707 + 192 Protein_353 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 327064..391030 63966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T95757 WP_000813254.1 NZ_CP026768:368694-368849 [Shigella flexneri Y]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T95757 NZ_CP026768:368694-368849 [Shigella flexneri Y]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT95757 NZ_CP026768:c368682-368624 [Shigella flexneri Y]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References