Detailed information of TA system TA095742

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4274917..4275142
• Replicon: chromosome
• Accession: NZ_CP026766
• Organism: Shigella boydii strain 59-248

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: C1P58_RS22040
• Protein ID: WP_000813254.1
• Coordinates: 4274917..4275072 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	4275084..4275142 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C1P58_RS21995	4270211..4270417	-	207	Protein_4170	integrase	-
C1P58_RS26400	4270407..4270487	-	81	Protein_4171	tail fiber assembly protein	-
C1P58_RS26275	4270490..4271011	-	522	WP_192940938.1	hypothetical protein	-
C1P58_RS26280	4271032..4271697	-	666	WP_004981765.1	hypothetical protein	-
C1P58_RS22005	4271684..4272274	-	591	WP_073691607.1	DUF2313 domain-containing protein	-
C1P58_RS22010	4272274..4272432	-	159	WP_000281422.1	hypothetical protein	-
C1P58_RS22015	4272514..4273670	+	1157	WP_094096479.1	IS3 family transposase	-
C1P58_RS22025	4273714..4274469	-	756	Protein_4177	DUF968 domain-containing protein	-
C1P58_RS22030	4274471..4274749	-	279	WP_000929754.1	hypothetical protein	-
C1P58_RS22040	4274917..4275072	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	4275084..4275142	+	59	-	-	Antitoxin
C1P58_RS22055	4275724..4276140	-	417	WP_005069274.1	hypothetical protein	-
C1P58_RS22060	4276237..4276692	-	456	WP_000335373.1	ead/Ea22-like family protein	-
C1P58_RS22065	4276679..4276984	-	306	WP_001266147.1	DUF4406 domain-containing protein	-
C1P58_RS22070	4276981..4277403	-	423	WP_134802472.1	DUF977 family protein	-
C1P58_RS22075	4277444..4278514	-	1071	WP_001262382.1	hypothetical protein	-
C1P58_RS22080	4278586..4279011	-	426	WP_000693847.1	Rha family transcriptional regulator	-
C1P58_RS22085	4279008..4279262	-	255	WP_001072337.1	hypothetical protein	-
C1P58_RS22090	4279342..4279761	+	420	WP_000233320.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4245770..4298187	52417

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T95742 WP_000813254.1 NZ_CP026766:c4275072-4274917 [Shigella boydii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T95742 NZ_CP026766:c4275072-4274917 [Shigella boydii]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT95742 NZ_CP026766:4275084-4275142 [Shigella boydii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin